CALM Human
Human brain tissue.
Calmodulin, CaM, CALM.
Sterile Filtered White lyophilized (freeze-dried) powder.
Greater than 95.0%.
Description
Product Specs
Calmodulin, CaM, CALM.
Human brain tissue.
Product Science Overview
Calmodulin is a small protein composed of 148 amino acids, with a molecular weight of approximately 16.7 kDa . It has two symmetrical globular domains (N- and C-domains), each containing a pair of EF-hand motifs, which are helix-loop-helix structures that bind calcium ions . These domains are connected by a flexible central linker, allowing calmodulin to bind a total of four Ca²⁺ ions . The binding of calcium induces a conformational change in calmodulin, enabling it to interact with various target proteins .
Calmodulin mediates a wide range of cellular processes, including:
- Inflammation
- Metabolism
- Apoptosis (programmed cell death)
- Smooth muscle contraction
- Intracellular movement
- Short-term and long-term memory
- Immune response
When calcium binds to calmodulin, it forms a Ca²⁺/calmodulin complex that can interact with and regulate numerous enzymes, ion channels, and other proteins . For example, the Ca²⁺/calmodulin complex can activate calcium pumps that remove calcium from the cytoplasm, thereby regulating downstream cellular responses .
Calmodulin’s ability to recognize and bind to a diverse range of target proteins is largely due to its structural flexibility . The flexible central linker and the open-closed conformational cycling of the N- and C-domains in the Ca²⁺-bound state allow calmodulin to adapt to different target proteins . This flexibility, combined with the predominantly hydrophobic nature of its binding interactions, enables calmodulin to recognize approximately 300 different target proteins .
