CACYBP Antibody

Calcyclin Binding Protein (CACYBP), also known as S100A6 binding protein, is a protein encoded by the CACYBP gene. This protein is involved in various cellular processes, including calcium-dependent ubiquitination and proteasomal degradation of target proteins. The mouse anti-human CACYBP antibody is used in research to study the protein’s function and its role in different biological pathways.

The CACYBP gene is located on chromosome 1 in both humans and mice. In humans, it is situated at 1q25.1, while in mice, it is found at 1H2.1 . The gene encodes a protein that consists of several domains responsible for its interaction with other proteins and its involvement in cellular processes.

CACYBP plays a crucial role in the ubiquitin-proteasome pathway, a system responsible for degrading unneeded or damaged proteins. It acts as a molecular bridge in ubiquitin E3 complexes, facilitating the ubiquitination and subsequent degradation of target proteins . One of its well-known targets is beta-catenin, a protein involved in cell adhesion and signaling. By regulating the degradation of beta-catenin, CACYBP influences various cellular processes, including cell proliferation and differentiation .

CACYBP interacts with several proteins, including SKP1A and SIAH1 . These interactions are essential for its function in the ubiquitin-proteasome pathway. Additionally, CACYBP is part of a complex with HSP90, a chaperone protein involved in stress response . This interaction highlights the role of CACYBP in cellular stress mechanisms.

The expression and function of CACYBP have been linked to various diseases. For instance, it has been implicated in cancer, where its role in protein degradation can affect tumor growth and progression . Additionally, CACYBP’s involvement in the immune response has been studied, particularly in the context of macrophage recruitment and inflammation .

The mouse anti-human CACYBP antibody is a valuable tool in research. It allows scientists to study the protein’s expression, localization, and function in different cell types and tissues. This antibody is used in various techniques, including Western blotting, immunohistochemistry, and immunoprecipitation, to investigate the role of CACYBP in health and disease.