C10ORF54 Human

C10orf54 is a transmembrane protein that consists of 310 amino acids and has a predicted molecular weight of approximately 33.7 kDa . The protein is glycosylated and contains several important domains that contribute to its function. It is expressed in various tissues, with notable expression in immune cells such as T cells and dendritic cells .

The primary function of C10orf54 is as an immunoregulatory receptor. It plays a crucial role in inhibiting T-cell responses, which is essential for maintaining immune homeostasis and preventing autoimmunity . This inhibitory function is mediated through its interaction with other immune checkpoint proteins, making it a potential target for cancer immunotherapy.

Additionally, C10orf54 has been implicated in the differentiation of embryonic stem cells by inhibiting BMP4 signaling . This suggests that the protein may have broader roles in development and cellular differentiation beyond its immunoregulatory functions.

Recombinant C10orf54 protein is produced using various expression systems, including HEK293T cells and Sf9 Baculovirus cells . The recombinant protein is typically purified using affinity chromatography techniques, ensuring high purity and functionality. It is available in different quantities and is used in research to study its biological functions and potential therapeutic applications .

Due to its role in immune regulation, C10orf54 is a promising target for cancer immunotherapy. By inhibiting this protein, it may be possible to enhance T-cell responses against tumors, improving the efficacy of existing treatments. Additionally, its involvement in stem cell differentiation makes it a potential target for regenerative medicine and developmental biology research .