BMPR1A Human, IgG-His
Sf9, Baculovirus cells.
BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, Bone Morphogenetic Protein Receptor Type 1A, Bone Morphogenetic Protein Receptor, Type IA, Serine/Threonine-Protein Kinase Receptor R5, Activin Receptor-Like Kinase 3, BMP Type-1A Receptor, EC 2.7.11.30, ALK-3, Bone Morphogenetic Protein Receptor Type-1A, Activin A Receptor, Type II-Like Kinase 3, CD292 Antigen, EC 2.7.1.
Description
BMPR1A Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 371 amino acids (24-152a.a.) and having a molecular mass of 41.4kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
BMPR1A is fused with a 242 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, Bone Morphogenetic Protein Receptor Type 1A, Bone Morphogenetic Protein Receptor, Type IA, Serine/Threonine-Protein Kinase Receptor R5, Activin Receptor-Like Kinase 3, BMP Type-1A Receptor, EC 2.7.11.30, ALK-3, Bone Morphogenetic Protein Receptor Type-1A, Activin A Receptor, Type II-Like Kinase 3, CD292 Antigen, EC 2.7.1.
Sf9, Baculovirus cells.
ADPQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H.
Product Science Overview
Bone Morphogenetic Protein Receptor-1A (BMPR1A) is a crucial protein in the human body, playing a significant role in various biological processes. This article delves into the background, structure, function, and significance of BMPR1A, particularly focusing on its recombinant form with an IgG-His tag.
BMPR1A is a transmembrane serine/threonine kinase receptor that belongs to the transforming growth factor-beta (TGF-β) superfamily . The human recombinant form of BMPR1A, tagged with IgG-His, is produced in Chinese Hamster Ovary (CHO) cells. This recombinant protein is a glycosylated homodimer chain containing 2x362 amino acids, with a total molecular mass of approximately 80.8 kDa .
BMPR1A plays a pivotal role in transmitting chemical signals from the cell membrane to the nucleus. When BMPR1A binds to its ligands, it activates a group of related proteins known as SMAD proteins . These proteins then transduce signals that regulate various cellular processes, including growth, differentiation, and apoptosis .
The ligands for BMPR1A are members of the TGF-β superfamily, including Bone Morphogenetic Proteins (BMPs) such as BMP2, BMP4, BMP6, and BMP7 . Upon ligand binding, BMPR1A forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases . This complex is essential for the activation of downstream signaling pathways, including the Akt and NF-kappaB pathways .
BMPR1A is essential for various developmental processes. For instance, BMPR1A null mice die at embryonic day 8.0 due to the lack of mesoderm specification, highlighting its vital role in gastrulation . Additionally, BMPR1A is involved in maintaining stable stem cell populations by repressing WNT signaling . It also plays a role in apoptosis, adipocyte development, and cell differentiation .
Mutations in the BMPR1A gene are associated with several hereditary conditions, including Juvenile Polyposis Syndrome and Hereditary Mixed Polyposis Syndrome . These conditions are characterized by the development of numerous polyps in the gastrointestinal tract, which can increase the risk of colorectal cancer .
