BCAT1 Antibody
Description
Product Specs
Product Science Overview
Branched Chain Amino-Acid Transaminase 1 (BCAT1) is a crucial enzyme involved in the metabolism of branched-chain amino acids (BCAAs), which include leucine, isoleucine, and valine. BCAT1 is encoded by the BCAT1 gene and is primarily located in the cytoplasm of cells . This enzyme plays a significant role in the reversible transamination of BCAAs and glutamate, facilitating the first step in the catabolic pathway of these essential amino acids .
BCAT1 is essential for maintaining cellular homeostasis and metabolic balance. It is particularly important in tissues with high metabolic activity, such as the brain and muscles. The enzyme’s activity is crucial for the synthesis of neurotransmitters and the regulation of energy production . Additionally, BCAT1 has been implicated in various physiological and pathological processes, including cancer metabolism, muscle atrophy, and neurological disorders .
Recent studies have highlighted the role of BCAT1 in cancer, particularly in glioblastoma, a highly malignant brain tumor. BCAT1 expression is upregulated in glioblastoma cells, contributing to the tumor’s growth and resistance to differentiation . The enzyme’s activity supports the metabolic demands of rapidly proliferating cancer cells and helps maintain an immunosuppressive microenvironment, which hinders the effectiveness of immunotherapies . Targeting BCAT1 in combination with other metabolic inhibitors has shown promise in preclinical models as a potential therapeutic strategy for glioblastoma .
Mouse anti-human BCAT1 antibodies are monoclonal antibodies developed to specifically recognize and bind to the human BCAT1 protein. These antibodies are valuable tools in research and diagnostic applications. They are used in various assays, including Western blotting, immunohistochemistry, and flow cytometry, to detect and quantify BCAT1 expression in human tissues and cell lines. The specificity and high affinity of these antibodies make them essential for studying BCAT1’s role in different biological contexts and disease states.
