BAFF R Human
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
The BAFF-R is purified by proprietary chromatographic techniques.
Product Specs
ASSPAPRTALQPQESVGAGAGEAALPLPG.
Product Science Overview
The B-cell Activating Factor Receptor (BAFFR), also known as TNFRSF13C, is a crucial receptor in the immune system, particularly in the development and survival of B cells. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and plays a significant role in the maturation and maintenance of B cells.
BAFFR is structurally unique within the TNFR superfamily. Unlike most members that have several extracellular cysteine-rich domains (CRDs), BAFFR contains only a partial CRD. This partial CRD is essential for ligand binding and self-assembly . The receptor is encoded by the TNFRSF13C gene and is expressed on the surface of all human peripheral B cell subsets, except for plasma cells and centroblasts in the dark zone of germinal centers .
BAFFR is a primary pro-survival receptor for B cells. Its function is highlighted by the fact that a homozygous deletion within exon 2 of the TNFRSF13C gene leads to a nearly complete block of B cell development at the immature/transitional stage . This results in immunodeficiency characterized by B-lymphopenia, agammaglobulinemia, and impaired humoral immune responses .
The expression of BAFFR begins when immature B cells develop into transitional B cells. These cells receive BAFFR-dependent pro-survival signals that rescue them from premature cell death . The receptor’s expression is upregulated following the expression of functional B cell antigen receptors (BCR), which enhances BAFFR expression by immature and transitional B cells .
Recombinant human BAFFR is produced using recombinant DNA technology, which involves inserting the gene encoding BAFFR into a suitable expression system, such as bacteria or mammalian cells. This allows for the production of large quantities of the receptor for research and therapeutic purposes. Recombinant BAFFR is used in various studies to understand its role in B cell biology and its potential as a therapeutic target in diseases such as autoimmune disorders and B cell malignancies .
BAFFR is implicated in several clinical conditions. High expression of BAFF and its receptor is associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis . Additionally, BAFFR is a potential therapeutic target in B cell malignancies, where its signaling pathways can be modulated to control the survival and proliferation of malignant B cells .
