AURKB Antibody

Aurora Kinase B is a serine/threonine kinase that plays a crucial role in the regulation of mitosis and cytokinesis. It is a member of the Aurora kinase family, which also includes Aurora Kinase A and Aurora Kinase C. Aurora Kinase B is a part of the Chromosomal Passenger Complex, which ensures proper chromosome segregation and cytokinesis during cell division .

Aurora Kinase B was first identified in humans in 1998 through a polymerase chain reaction screen for kinases overexpressed in cancers . The gene encoding Aurora Kinase B is located on chromosome 17p13.1 in humans . The protein is composed of 344 amino acids and has a molecular weight of approximately 39 kDa .

Aurora Kinase B is essential for the attachment of the mitotic spindle to the centromere and for cytokinesis . It localizes to the centromere during prometaphase and metaphase and to the central spindle during anaphase . Aurora Kinase B regulates the correction of kinetochore-microtubule attachment errors and ensures proper chromosome alignment and segregation . Overexpression of Aurora Kinase B has been observed in several human cancers and is associated with poor prognosis .

Mouse anti-human Aurora Kinase B antibodies are monoclonal antibodies produced by immunizing mice with human Aurora Kinase B protein. These antibodies are used in various research applications, including Western blotting, immunohistochemistry, and immunofluorescence . They are valuable tools for studying the expression, localization, and function of Aurora Kinase B in human cells.

Aurora Kinase B is a promising target for cancer therapy due to its critical role in cell division and its overexpression in cancer cells . Inhibitors of Aurora Kinase B have been extensively studied as potential anticancer agents. These inhibitors aim to disrupt the function of Aurora Kinase B, leading to cell cycle arrest and apoptosis in cancer cells .