ASFV P30

African Swine Fever Virus (ASFV) is a highly contagious and lethal virus that affects domestic pigs and wild boars. It is the only member of the Asfarviridae family and is known for causing a hemorrhagic fever with mortality rates approaching 100% . ASFV is a large, complex virus with a double-stranded DNA genome that encodes numerous structural and non-structural proteins .

One of the key structural proteins of ASFV is P30, also known as CP204L. P30 is a membrane phosphoprotein that plays a crucial role in the virus’s ability to infect host cells . It is involved in the early stages of viral infection and is one of the most immunogenic proteins produced during ASFV infection . This makes P30 a valuable target for serological detection and surveillance of ASFV .

P30 interacts with several host cellular proteins, which suggests it may play a regulatory role in signal transduction and other cellular processes . Research has identified seven host proteins that interact with P30, including DAB2, RPSA, OAS1, PARP9, CAPG, ARPC5, and VBP1 . These interactions are believed to be involved in endocytosis, actin cytoskeleton regulation, and innate immunity .

The P30 protein is essential for the internalization of ASFV into host cells, making it a critical factor in the virus’s ability to establish infection . Its immunogenic properties also make it a key target for the development of diagnostic tools and potential vaccines .