ARL9 Human
Description
ARL9 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The ARL9 gene is located on chromosome 4 and encodes a protein that consists of 143 amino acids . The human recombinant ARL9 protein is produced in Escherichia coli and is a single, non-glycosylated polypeptide chain with a molecular mass of approximately 15.9 kDa . The recombinant protein is often fused with a 20 amino acid His-tag at the N-terminus to facilitate purification .
ARL9, like other small GTPases, functions as a molecular switch by cycling between an active GTP-bound state and an inactive GDP-bound state . This cycling is crucial for its role in intracellular signaling pathways. The specific biological functions of ARL9 are still being investigated, but it is believed to be involved in processes such as:
- Vesicle Trafficking: ARL9 may play a role in the transport of vesicles within cells, similar to other ARF family members.
- Cytoskeletal Organization: It may also be involved in the regulation of the cytoskeleton, which is essential for maintaining cell shape and enabling cell movement.
- Signal Transduction: ARL9 might participate in signaling pathways that regulate various cellular activities.
Recombinant ARL9 protein is used in various research applications to study its function and role in cellular processes. It is also utilized in assays to investigate the interactions between ARL9 and other proteins or molecules. The availability of recombinant ARL9 protein facilitates the study of its structure, function, and potential therapeutic applications.
The recombinant ARL9 protein is typically stored at 4°C if it will be used within 2-4 weeks. For longer storage periods, it is recommended to store the protein at -20°C with the addition of a carrier protein such as 0.1% HSA or BSA to prevent degradation . It is important to avoid multiple freeze-thaw cycles to maintain the protein’s stability and functionality.
