APOL4 Human

Apolipoprotein L 4 (APOL4) is a member of the apolipoprotein L family, which plays a crucial role in lipid metabolism and transport. This protein is involved in the exchange and transport of lipids throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver .

APOL4 is encoded by the APOL4 gene, which produces two transcript variants encoding different isoforms. One of these isoforms is a secreted protein, while the other remains intracellular . The recombinant form of APOL4 is typically produced in Escherichia coli (E. coli) and is available in various forms for research purposes .

The primary function of APOL4 is to facilitate lipid exchange and transport. It plays a significant role in reverse cholesterol transport, a process where cholesterol is transported from peripheral tissues back to the liver for excretion. This function is vital for maintaining lipid homeostasis and preventing the accumulation of cholesterol in peripheral tissues .

APOL4 is highly expressed in several tissues, including the spinal cord, placenta, adrenal gland, spleen, bone marrow, uterus, trachea, mammary gland, and testis . Its widespread expression suggests that it may have diverse physiological roles in different tissues.

Recombinant APOL4 is used extensively in research to study its function and role in lipid metabolism. It is also used in blocking assays and control experiments to investigate the interactions of APOL4 with other proteins and molecules . The recombinant protein is typically purified and supplied in a liquid form, with a concentration of ≥5.0 mg/mL .