ANKRD1 Human
Ankyrin Repeat Domain 1 Human Recombinant
Cat. No.
BT19246
Source
E.coli.
Synonyms
Ankyrin Repeat Domain 1 (Cardiac Muscle), Cardiac Ankyrin Repeat Protein, Cytokine-Inducible Gene C-193 Protein, Ankyrin Repeat Domain-Containing Protein 1, Cytokine-Inducible Nuclear Protein, Liver Ankyrin Repeat Domain 1, BA320F15.2, CARP, ALRP, CVARP, MCARP, HA1A2, C193.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
ANKRD1 Human Recombinant produced in E. coli is a single polypeptide chain containing 342 amino acids (1-319) and having a molecular mass of 38.6 kDa.
ANKRD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
ANKRD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
ANKRD1, a nuclear transcription factor, is involved in endothelial cell activation and negatively regulates the expression of cardiac genes.
Description
Recombinant human ANKRD1, expressed in E. coli, is a 38.6 kDa polypeptide chain comprising 342 amino acids (residues 1-319). It includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile filtered solution.
Formulation
The ANKRD1 solution is supplied in 20mM Tris-HCl buffer with a pH of 8.5, 0.2M NaCl, 5mM DTT, and 50% glycerol.
Stability
For short-term storage (up to 4 weeks), store the vial at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 85% as determined by SDS-PAGE analysis.
Synonyms
Ankyrin Repeat Domain 1 (Cardiac Muscle), Cardiac Ankyrin Repeat Protein, Cytokine-Inducible Gene C-193 Protein, Ankyrin Repeat Domain-Containing Protein 1, Cytokine-Inducible Nuclear Protein, Liver Ankyrin Repeat Domain 1, BA320F15.2, CARP, ALRP, CVARP, MCARP, HA1A2, C193.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGS MMVLKVE ELVTGKKNGN GEAGEFLPED FRDGEYEAAV TLEKQEDLKT LLAHPVTLGE QQWKSEKQRE AELKKKKLEQ RSKLENLEDL EIIIQLKKRK KYRKTKVPVV KEPEPEIITE PVDVPTFLKA ALENKLPVVE KFLSDKNNPD VCDEYKRTAL HRACLEGHLA IVEKLMEAGA QIEFRDMLES TAIHWASRGG NLDVLKLLLN KGAKISARDK LLSTALHVAV RTGHYECAEH LIACEADLNA KDREGDTPLH DAVRLNRYKM IRLLIMYGAD LNIKNCAGKT PMDLVLHWQN GTKAIFDSLR ENSYKTSRIA TF
Product Science Overview
Structure and Function
Expression and Localization
ANKRD1 is predominantly expressed in the heart, although it can also be found in other tissues. Its expression is high in the early embryonic heart but decreases to lower levels in the adult heart . The protein has a dual nuclear-cytoplasmic localization, meaning it can be found both in the nucleus and the cytoplasm of cells .
Role in Cardiovascular Health
Recombinant ANKRD1
Recombinant ANKRD1 refers to the protein produced through recombinant DNA technology, which involves inserting the gene encoding ANKRD1 into a host organism to produce the protein in large quantities. This recombinant protein can be used in various research applications to study its function and role in disease .
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