Angiotensin
Angiotensin
Cat. No.
BT13283
Source
Synthetic.
Synonyms
Angiotensinogen, Serpin A8, ANHU, SERPINA8.
Appearance
Sterile Filtered white lyophilized powder.
Purity
Greater than 98.0% as determined by RP-HPLC.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Angiotensin contains a total of 8 amino acids having a molecular weight of 1031.2 Dalton and a molecular formula of C49H70N14O11.
Product Specs
Introduction
Angiotensin, an oligopeptide found in the bloodstream, acts as a potent vasoconstrictor, elevating blood pressure and stimulating the release of aldosterone from the adrenal cortex. This peptide, known for its dipsogenic properties (inducing thirst), originates from angiotensinogen, a precursor serum globulin synthesized in the liver. Angiotensin plays a crucial role in the renin-angiotensin system, which regulates blood pressure and fluid balance. The gene encoding pre-angiotensinogen, also known as angiotensinogen precursor, is primarily expressed in the liver. In response to a decrease in blood pressure, the enzyme renin cleaves pre-angiotensinogen, yielding angiotensin I. Subsequently, angiotensin-converting enzyme (ACE) acts upon angiotensin I to generate angiotensin II, the physiologically active form. This cascade of events highlights the significance of angiotensin in maintaining blood pressure homeostasis and its implication in the pathogenesis of hypertension and preeclampsia.
Description
Angiotensin, comprised of 8 amino acids, exhibits a molecular weight of 1031.2 Daltons and is represented by the molecular formula C49H70N14O11.
Physical Appearance
The product appears as a sterile-filtered, white, lyophilized powder.
Solubility
For reconstitution, it is advised to dissolve the lyophilized Angiotensin in sterile 18MΩ-cm H2O, ensuring a final concentration ranging from 100 µg/ml to 10 mg/ml.
Stability
While lyophilized Angiotensin demonstrates stability at room temperature for a period of 3 weeks, it is recommended to store it in a desiccated state below -18°C. Upon reconstitution, Serpin A8 should be stored at 4°C for a duration of 2-7 days. For long-term storage, it is advisable to keep it below -18°C. It is important to avoid repeated freeze-thaw cycles to maintain product integrity.
Purity
The purity of the product exceeds 98.0% as determined by RP-HPLC analysis.
Synonyms
Angiotensinogen, Serpin A8, ANHU, SERPINA8.
Source
Synthetic.
Amino Acid Sequence
Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH.
Product Science Overview
Discovery and History
Structure and Types
Angiotensin is derived from a precursor molecule called angiotensinogen, which is a serum globulin produced in the liver . Angiotensinogen is an α-2-globulin and a member of the serpin family of proteins . It is cleaved by the enzyme renin to produce angiotensin I, which is then converted to angiotensin II by the angiotensin-converting enzyme (ACE) found in the lungs and kidneys .
There are four different forms of angiotensin, denoted by Roman numerals I to IV. Among these, angiotensin II is the most active form and has the most significant physiological effects .
Function and Mechanism
Angiotensin II has several important functions in the body:
- Vasoconstriction: It causes the blood vessels to constrict, leading to an increase in blood pressure .
- Aldosterone Release: It stimulates the adrenal cortex to release aldosterone, which promotes sodium retention by the kidneys .
- Thirst Stimulation: It triggers the sensation of thirst through the hypothalamus .
- Antidiuretic Hormone Release: It stimulates the release of antidiuretic hormone (ADH) from the pituitary gland, which causes the kidneys to reabsorb water .
Clinical Significance
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