ALCAM (CD166) Human
Activated Leukocyte Cell Adhesion Molecule, CD166 Antigen, MEMD, Activated Leucocyte Cell Adhesion Molecule, CD166, ALCAM.
Greater than 90.0% as determined by SDS-PAGE.
Description
ALCAM Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 742 amino acids (28-527a.a.) and having a molecular mass of 83.1kDa (Molecular size on SDS-PAGE will appear at approximately 70-100 kDa).
CD166 is expressed with a 239 amino acid hIgGHis tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Activated Leukocyte Cell Adhesion Molecule, CD166 Antigen, MEMD, Activated Leucocyte Cell Adhesion Molecule, CD166, ALCAM.
ADPWYTVNSA YGDTIIIPCR LDVPQNLMFG KWKYEKPDGS PVFIAFRSST KKSVQYDDVP EYKDRLNLSE NYTLSISNAR ISDEKRFVCM LVTEDNVFEA PTIVKVFKQP SKPEIVSKAL FLETEQLKKL GDCISEDSYP DGNITWYRNG KVLHPLEGAV VIIFKKEMDP VTQLYTMTST
LEYKTTKADI QMPFTCSVTY YGPSGQKTIH SEQAVFDIYY PTEQVTIQVL PPKNAIKEGD NITLKCLGNG NPPPEEFLFY LPGQPEGIRS SNTYTLTDVR RNATGDYKCS LIDKKSMIAS TAITVHYLDL SLNPSGEVTR QIGDALPVSC TISASRNATV VWMKDNIRLR SSPSFSSLHY
QDAGNYVCET ALQEVEGLKK RESLTLIVEG KPQIKMTKKT DPSGLSKTII CHVEGFPKPA IQWTITGSGS VINQTEESPY INGRYYSKII ISPEENVTLT CTAENQLERT VNSLNVSANE NREKVNDQAK LIVGIVVGLL LAALEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL
MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA
LHNHYTQKSL SLSPGKHHHH HH.
Product Science Overview
ALCAM was discovered over two decades ago and has since been established as a pivotal cell adhesion protein mediating both homotypic (same cell type) and heterotypic (different cell types) cell-cell adhesions . The protein structure of ALCAM includes five extracellular immunoglobulin-like domains, a single transmembrane domain, and a short cytoplasmic tail .
ALCAM is ubiquitously present in the body and is involved in numerous physiological processes such as neurogenesis, angiogenesis, hematopoiesis, and leukocyte trafficking . It is also crucial for the maintenance of hematopoietic stem cells in bone marrow niches . In the context of cancer, ALCAM is aberrantly expressed in various cancer types and has been shown to be a regulator of cancer metastasis .
The expression of ALCAM in cancer tissues has significant prognostic value depending on the type of cancer. High expression of ALCAM is associated with poor prognosis in several solid tumors, including breast cancer and melanoma . A truncated form of ALCAM, known as soluble ALCAM (sALCAM), is found in circulation and has been suggested as a prognostic indicator and potential therapeutic tool .
