ADRM1 Antibody

Adhesion Regulating Molecule 1, Mouse Anti Human
Cat. No.
BT11585
Source
Synonyms
Proteasomal ubiquitin receptor ADRM1, 110 kDa cell membrane glycoprotein, Gp110, Adhesion-regulating molecule 1, ARM-1, Proteasome regulatory particle non-ATPase 13, hRpn13, Rpn13 homolog, ADRM1, ARM1, Rpn13.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Product Specs

Introduction
ADRM1, also known as Proteasomal ubiquitin receptor ADRM1, is a plasma membrane protein that plays a crucial role in ubiquitin-mediated protein degradation and cell adhesion. This protein acts as a receptor for ubiquitinated proteins, targeting them to the proteasome for degradation. ADRM1 specifically recruits and enhances the activity of the deubiquitinating enzyme UCHL5 at the 26S proteasome. Additionally, it is involved in promoting cell adhesion. ADRM1 is likely to undergo O-linked glycosylation, a common post-translational modification. Notably, its expression is upregulated by gamma interferon in certain cancer cell lines.
Physical Appearance
The product is a clear and colorless solution that has been sterilized by filtration.
Formulation
This antibody solution is supplied at a concentration of 1 milligram per milliliter (mg/ml) and is formulated in a phosphate-buffered saline (PBS) solution with a pH of 7.4. It also contains 10% glycerol as a stabilizing agent and 0.02% sodium azide as a preservative.
Storage Procedures
To ensure product stability, store at 4°C for up to one month. For extended storage periods exceeding one month, it is recommended to store the antibody at -20°C. Avoid repeated freeze-thaw cycles.
Stability / Shelf Life
The product remains stable for 12 months when stored at -20°C and for 1 month when stored at 4°C.
Applications
This antibody has undergone rigorous testing in various applications, including ELISA, Western blot analysis, Flow cytometry, and Immunocytochemistry/Immunofluorescence (ICC/IF), demonstrating its high specificity and reactivity. For optimal results, it is recommended to titrate the antibody to determine the optimal working concentration for your specific application.
Synonyms
Proteasomal ubiquitin receptor ADRM1, 110 kDa cell membrane glycoprotein, Gp110, Adhesion-regulating molecule 1, ARM-1, Proteasome regulatory particle non-ATPase 13, hRpn13, Rpn13 homolog, ADRM1, ARM1, Rpn13.
Purification Method
ADRM1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT34C2AT.
Immunogen
Anti-human ADRM1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ADRM1 protein 1-407 amino acids purified from E. coli.
Ig Subclass
Mouse IgG2b heavy chain and k light chain.

Product Science Overview

Structure and Function

ADRM1 is a receptor for ubiquitin, a small regulatory protein that tags other proteins for degradation. By binding to ubiquitinated proteins, ADRM1 facilitates their recognition and processing by the proteasome. This process is vital for the regulation of protein turnover, which in turn affects numerous cellular functions such as cell cycle progression, apoptosis, and DNA repair .

Role in Cancer

Recent studies have highlighted the significance of ADRM1 in cancer development and progression. Elevated levels of ADRM1 have been observed in various types of cancers, including bladder cancer. In bladder cancer, high ADRM1 expression is associated with poor prognosis and increased tumor aggressiveness. ADRM1’s role in cancer is linked to its involvement in regulating immune-related pathways and its interaction with immune checkpoints such as CD274 (PD-L1), PDCD1 (PD-1), and PDCD1LG2 (PD-L2) .

Mouse Anti Human ADRM1 Antibodies

Mouse anti-human ADRM1 antibodies are monoclonal antibodies developed to specifically target the human ADRM1 protein. These antibodies are used in research to study the expression and function of ADRM1 in various biological contexts. They are particularly valuable in immunohistochemistry (IHC) and other immunoassays to detect ADRM1 in tissue samples and cell lines .

Applications in Research

The use of mouse anti-human ADRM1 antibodies has facilitated numerous studies aimed at understanding the role of ADRM1 in health and disease. For instance, these antibodies have been employed to investigate the expression patterns of ADRM1 in cancer tissues, providing insights into its potential as a biomarker for cancer diagnosis and prognosis. Additionally, research utilizing these antibodies has contributed to the development of targeted therapies aimed at modulating ADRM1 activity to improve cancer treatment outcomes .

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