ACSF2 Antibody
Acyl-CoA Synthetase Family Member 2, PPARG Binding, Long Chain Fatty Acid Acyl Co-A Ligase Like, Acyl-CoA Synthetase Family Member 2, Mitochondrial, EC 6.2.1.26, EC 6.2.1.-, FLJ20920, EC 6.2.1, AVYV493, ACSMW, Acyl-CoA synthetase family member 2, mitochondrial.
Description
Product Specs
Acyl-CoA Synthetase Family Member 2, PPARG Binding, Long Chain Fatty Acid Acyl Co-A Ligase Like, Acyl-CoA Synthetase Family Member 2, Mitochondrial, EC 6.2.1.26, EC 6.2.1.-, FLJ20920, EC 6.2.1, AVYV493, ACSMW, Acyl-CoA synthetase family member 2, mitochondrial.
ACSF2 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
PAT18B4AT.
Anti-human ACSF2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ACSF2 amino acids 42-615 purified from E. coli.
Mouse IgG1 heavy chain and κ light chain.
Product Science Overview
Acyl-CoA Synthetase Family Member 2 (ACSF2) is a protein-coding gene that plays a crucial role in fatty acid metabolism. This gene is part of the acyl-CoA synthetase family, which is responsible for catalyzing the initial reaction in fatty acid metabolism by forming a thioester with CoA . The ACSF2 gene is also known by several aliases, including Medium-Chain Acyl-CoA Ligase and Mitochondrial Acyl-CoA Synthetase .
The ACSF2 gene is located on chromosome 17 and is involved in various metabolic pathways, including fatty acid metabolism and general metabolism . The protein encoded by this gene has ligase activity, which is essential for the activation of fatty acids by CoA to produce acyl-CoA . This process is the first step in fatty acid metabolism and is crucial for the proper functioning of cellular metabolic processes.
ACSF2 enables medium-chain fatty acid-CoA ligase activity, which is predicted to be involved in the fatty acid metabolic process . The enzyme has a preference for medium-chain substrates and plays a significant role in adipocyte differentiation . This activity is essential for the conversion of fatty acids into their respective acyl-CoA derivatives, which are then utilized in various metabolic pathways.
The ACSF2 gene has been implicated in several health conditions due to its role in fatty acid metabolism. Dysregulation of this gene can lead to metabolic disorders and has been associated with conditions such as obesity, diabetes, and cardiovascular diseases . Additionally, ACSF2 is involved in the metabolic reprogramming of cancer cells, making it a potential target for cancer therapy .
The mouse anti-human ACSF2 antibody is used in various research applications to study the expression and function of the ACSF2 protein in human tissues. This antibody is reactive with human, mouse, and rat samples and is utilized in techniques such as Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), and Enzyme-Linked Immunosorbent Assay (ELISA) . The use of this antibody helps in understanding the role of ACSF2 in different biological processes and disease states.
