ACAT2 Human
Description
Product Specs
VIFGHVLAAG CGQNPVRQAS VGAGIPYSVP AWSCQMICGS GLKAVCLAVQ SIGIGDSSIV VAGGMENMSK APHLAYLRTG VKIGEMPLTD SILCDGLTDA FHNCHMGITA ENVAKKWQVS REDQDKVAVL SQNRTENAQK AGHFDKEIVP VLVSTRKGLI EVKTDEFPRH GSNIEAMSKL KPYFLTDGTG TVTPANASGI NDGAAAVVLM KKSEADKRGL TPLARIVSWS QVGVEPSIMG IGPIPAIKQA VTKAGWSLED VDIFEINEAF AAVSAAIVKE LGLNPEKVNI EGGAIALGHP LGASGCRILV TLLHTLERMG RSRGVAALCI GGGMGIAMCV QR.
Product Science Overview
The ACAA2 gene is located on chromosome 18 at band 18q21.1 . It encodes a protein that is approximately 41.9 kDa in size and consists of 397 amino acids . The protein contains 88 observed peptides and has a non-cleavable amino-terminal targeting signal, which is uncommon among mitochondrial matrix proteins .
The primary function of ACAA2 is to catalyze the final step of the mitochondrial fatty acid beta-oxidation spiral . This process involves the conversion of 3-ketoacyl-CoA to acetyl-CoA, which is a critical step in the breakdown of fatty acids to produce energy . Additionally, ACAA2 has been identified as a functional binding partner of BNIP3, linking fatty acid metabolism to cell apoptosis .
While no direct mutations or variants of the ACAA2 gene have been linked to specific clinical diseases, its locus has been associated with abnormal blood lipid levels, particularly HDL and LDL cholesterol levels . This association suggests a potential link between ACAA2 and an individual’s risk for coronary artery disease .
Research on ACAA2 has highlighted its role in cholesterol metabolism and systemic energy expenditure . For instance, overexpression of Acat2 in the liver has been shown to reduce body weight, improve glucose tolerance, and lower serum cholesterol levels in mice . These findings suggest that ACAA2 could be a potential therapeutic target for treating obesity and hypercholesterolemia .
