ZNRD1 Human
Description
Product Specs
Product Science Overview
The ZNRD1 protein contains two zinc ribbon domains, which are small protein motifs that coordinate zinc ions to stabilize their structure . These domains are crucial for the protein’s function in transcription regulation. The zinc ribbon domains are characterized by the presence of conserved cysteine and histidine residues that bind zinc ions, forming a stable structure essential for protein-protein interactions .
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Transcription Regulation: ZNRD1 is involved in the regulation of transcription, the process by which genetic information from DNA is copied into RNA. The zinc ribbon domains play a critical role in this process by interacting with other proteins involved in transcription .
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Multidrug Resistance: ZNRD1 has been found to modulate multidrug resistance, a phenomenon where cancer cells become resistant to a variety of chemotherapeutic drugs. This makes ZNRD1 a potential target for overcoming drug resistance in cancer therapy .
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Tumorigenesis: The protein encoded by ZNRD1 is also implicated in tumorigenesis, the process by which normal cells transform into cancer cells. It is believed that ZNRD1 may influence the expression of genes involved in cell proliferation and survival .
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Cell Cycle Regulation: ZNRD1 plays a role in the regulation of the cell cycle, the series of events that take place in a cell leading to its division and replication. Proper regulation of the cell cycle is crucial for maintaining normal cell growth and preventing uncontrolled cell proliferation .
Research on ZNRD1 has provided insights into its potential as a therapeutic target. For instance, studies have shown that manipulating the expression of ZNRD1 can affect the sensitivity of cancer cells to chemotherapeutic drugs, suggesting that ZNRD1 inhibitors could be used to enhance the efficacy of cancer treatments .
Additionally, ZNRD1 has been identified as a host factor that influences disease progression in HIV-positive individuals. A genome-wide association study found that variations in the ZNRD1 gene significantly affected HIV replication, highlighting its potential role in antiviral therapy .
