ZNF689 Human

ZNF689 contains 12 C2H2-type zinc fingers and one KRAB (Krüppel-associated box) domain . The C2H2-type zinc fingers are known for their role in binding to DNA, while the KRAB domain is typically involved in transcriptional repression. This combination suggests that ZNF689 may function as a transcriptional regulator, potentially repressing or activating the expression of specific genes .

ZNF689 is predicted to be involved in the regulation of transcription by RNA polymerase II, which is a key enzyme in the transcription of DNA into messenger RNA (mRNA) . It is also predicted to play a role in skeletal muscle cell differentiation and is active in the nucleus, where it can interact with DNA and other nuclear components .

Recombinant human ZNF689 protein is typically produced in Escherichia coli (E. coli) and is often fused to a His-tag at the N-terminus to facilitate purification . The recombinant protein is used in various research applications to study its function and role in gene regulation. The protein is usually stored in a buffer containing Tris-HCl, glycerol, and urea to maintain its stability .

As a transcriptional regulator, ZNF689 may be involved in various biological processes, including development, differentiation, and possibly tumorigenesis. Zinc finger proteins, in general, are known to play significant roles in multiple biological processes, including cell growth, apoptosis, and DNA repair .

The recombinant form of ZNF689 is used in research to understand its role in gene regulation and its potential involvement in diseases. Studies on ZNF689 can provide insights into the mechanisms of transcriptional regulation and the potential therapeutic targets for diseases where ZNF689 is implicated .