ZNF32 Human
Description
ZNF32 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Zinc Finger Protein 32 (ZNF32) is a member of the zinc finger protein family, which is the largest family of transcription factors in the human genome. These proteins are characterized by their zinc finger domains, which are finger-like structures that bind to DNA and play a crucial role in gene regulation .
ZNF32 contains multiple zinc finger motifs, typically of the Cys2His2 type, which is the most common zinc finger motif. Each zinc finger domain consists of approximately 30 amino acids and forms a compact, spherical structure stabilized by a zinc ion. The zinc ion is coordinated by cysteine and histidine residues, which are essential for the structural integrity and function of the protein .
ZNF32 functions primarily as a transcription factor, meaning it binds to specific DNA sequences and regulates the transcription of genes. This regulation is vital for various biological processes, including cell growth, differentiation, and apoptosis. ZNF32 is involved in the regulation of transcription by RNA polymerase II, which is responsible for transcribing most of the genes in eukaryotes .
Zinc finger proteins, including ZNF32, play significant roles in numerous biological processes. They are involved in metabolism, autophagy, immune responses, and the maintenance and differentiation of stem cells. Due to their diverse functions, zinc finger proteins are implicated in various diseases, particularly cancers. For instance, alterations in zinc finger proteins have been associated with hepatocellular carcinoma, a common type of liver cancer .
Recombinant ZNF32 refers to the protein produced through recombinant DNA technology. This involves inserting the gene encoding ZNF32 into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities. Recombinant ZNF32 is used in research to study its structure, function, and role in disease. It also has potential therapeutic applications, such as in gene therapy and as a target for drug development .
Research on ZNF32 and other zinc finger proteins is ongoing, with a focus on understanding their roles in health and disease. Artificial zinc finger proteins are being designed for various applications, including gene editing and the development of new treatments for diseases. The unique structural and functional properties of zinc finger proteins make them valuable tools in biotechnology and medicine .
