ZG16 Human

Zymogen Granule Protein 16 Homolog Human Recombinant

Cat. No.

BT28186

Source

Escherichia Coli.

Synonyms

Zymogen granule membrane protein 16, Zymogen granule protein 16, hZG16, Secretory lectin ZG16, ZG16, JCLN, JCLN1, ZG16A, FLJ43571, FLJ92276, MGC34820, MGC183567.

Appearance

Sterile filtered colorless solution.

Purity

Greater than 95% as determined by SDS-PAGE.

Usage

THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

ZG16 Human Recombinant produced in E. coli is a single polypeptide chain containing 174 amino acids (17-167) and having a molecular mass of 19kDa. ZG16 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction

Zymogen Granule Protein 16 Homolog (ZG16), a member of the jacalin lectin family, may be involved in protein trafficking. It could potentially act as a linker between the submembranous matrix on the inner side of the zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the trans-Golgi network (TGN). ZG16 is highly expressed in the liver but is also found in lower levels in the colon, ileum, and jejunum.

Description

Recombinant human ZG16, produced in E. coli, is a single polypeptide chain of 174 amino acids (residues 17-167) with a molecular weight of 19 kDa. A 23 amino acid His-tag is fused to the N-terminus of ZG16. The protein is purified using proprietary chromatographic techniques.

Physical Appearance

Clear, colorless, and sterile-filtered solution.

Formulation

The ZG16 solution is supplied at a concentration of 0.25 mg/ml in a buffer consisting of 20 mM Tris-HCl (pH 8.0), 0.15 M NaCl, 20% glycerol, and 1 mM DTT.

Stability

For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. Adding a carrier protein (0.1% HSA or BSA) is advised for long-term storage. Avoid repeated freeze-thaw cycles.

Purity

The purity is determined to be greater than 95% by SDS-PAGE analysis.

Synonyms

Zymogen granule membrane protein 16, Zymogen granule protein 16, hZG16, Secretory lectin ZG16, ZG16, JCLN, JCLN1, ZG16A, FLJ43571, FLJ92276, MGC34820, MGC183567.

Source

Escherichia Coli.

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSNAIQARS SSYSGEYGGG GGKRFSHSGN QLDGPITALR VRVNTYYIVG LQVRYGKVWS DYVGGRNGDL EEIFLHPGES VIQVSGKYKW YLKKLVFVTD KGRYLSFGKD SGTSFNAVPL HPNTVLRFIS GRSGSLIDAI GLHWDVYPTS CSRC.

Product Science Overview

Gene and Protein Structure

The ZG16B gene is located on chromosome 16p13.3 and encodes a protein that is approximately 22.6 kDa in size. The protein sequence includes a jacalin-like lectin domain, which is crucial for its carbohydrate-binding activity. The recombinant form of this protein is often expressed in HEK293T cells for research purposes.

Biological Function

ZG16B plays a significant role in the progression and metastasis of pancreatic tumors. It promotes the migration and invasion of pancreatic cancer cells through the TLR4/MyD88/NF-κB signaling pathway, without involving the TLR4/TRIF pathway. This makes it a potential target for therapeutic interventions in pancreatic cancer.

Clinical Significance

Diseases associated with ZG16B include Pancreatic Adenocarcinoma and other forms of adenocarcinoma. The protein’s role in tumor progression makes it a valuable biomarker for the diagnosis and prognosis of pancreatic cancer.

Research and Applications

Recombinant ZG16B protein is widely used in research to study its function and role in cancer biology. It is available in various forms and sizes, typically purified through affinity chromatography. Researchers use this protein to investigate its interactions with other cellular components and its potential as a therapeutic target.

Storage and Stability

The recombinant ZG16B protein is stable for up to 12 months when stored at -80°C, avoiding repeated freeze-thaw cycles. It is typically supplied in a buffer containing Tris-HCl, glycine, and glycerol to maintain its stability.

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ZG16 Human

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