ZFAND3 Human

ZFAND3 contains an AN1-type zinc finger domain, which is a specific type of zinc finger motif. Zinc finger motifs are small protein structural motifs that are stabilized by the coordination of one or more zinc ions . The AN1-type domain is known for its role in protein-protein interactions and is involved in various cellular processes, including transcriptional regulation .

ZFAND3 has been identified as a transcriptional regulator that plays a crucial role in the invasion of glioblastoma, a highly aggressive form of brain cancer . Research has shown that ZFAND3 can enhance the invasive capacity of glioblastoma cells by regulating the expression of genes related to cell motility and invasion . This makes ZFAND3 a potential target for therapeutic interventions in glioblastoma and other invasive cancers.

Additionally, ZFAND3 has been associated with sperm maturation in mice and has been linked to the susceptibility to type 2 diabetes in humans . These diverse roles highlight the importance of ZFAND3 in various physiological and pathological processes.

Recombinant ZFAND3 is produced using E. coli expression systems and is available for research purposes . The recombinant protein is typically purified and supplied in a liquid form, with a concentration of at least 5.0 mg/mL . It is used in various applications, including blocking assays and control experiments .

The study of ZFAND3 is ongoing, with researchers investigating its role in different cellular contexts and its potential as a therapeutic target. The ability to produce recombinant ZFAND3 allows scientists to conduct detailed studies on its function and interactions, paving the way for new insights into its role in health and disease.