ZCCHC17 Human
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Description
ZCCHC17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C.
To ensure long-term stability during storage, the addition of a carrier protein (0.1% HSA or BSA) is advised.
Repeated freeze-thaw cycles should be avoided.
MGSSHHHHHH SSGLVPRGSH MGSMNSGRPE TMENLPALYT IFQGEVAMVT DYGAFIKIPG CRKQGLVHRT HMSSCRVDKP SEIVDVGDKV WVKLIGREMK NDRIKVSLSM KVVNQGTGKD LDPNNVIIEQ EERRRRSFQD YTGQKITLEA VLNTTCKKCG CKGHFAKDCF MQPGGTKYSL IPDEEEEKEE AKSAEFEKPD PTRNPSRKRK KEKKKKKHRD RKSSDSDSSD SESDTGKRAR HTSKDSKAAK KKKKKKKHKK KHKE.
Product Science Overview
The Zinc Finger, CCHC Domain Containing 17 (ZCCHC17) is a protein encoded by the ZCCHC17 gene in humans. This protein is part of the zinc finger CCHC-type (ZCCHC) superfamily, which is characterized by the presence of a specific zinc finger motif known as the CCHC domain. This domain is defined by the sequence CX₂CX₄HX₄C, where C represents cysteine, H represents histidine, and X represents any amino acid .
The CCHC domain, also referred to as the “zinc knuckle,” is a small zinc-ligating domain that stabilizes its structure through the coordination of zinc ions. This domain is involved in various aspects of nucleic acid metabolism, including DNA transcription, RNA degradation, post-transcriptional gene silencing, and small RNA biogenesis .
ZCCHC17 is predicted to be involved in RNA stabilization and is primarily located in the nucleolus. It is also part of the cytosolic large ribosomal subunit . The protein’s functions are closely related to RNA metabolism, including transcriptional elongation, polyadenylation, translation, pre-messenger RNA splicing, RNA export, RNA degradation, microRNA and ribosomal RNA biogenesis, and post-transcriptional gene silencing .
The conservation of ZCCHC domains across different species, including yeast, Arabidopsis, and humans, suggests that these domains have biologically relevant functions. In humans, several ZCCHC-containing factors are derived from neofunctionalized retrotransposons and act as proto-oncogenes in various neoplastic processes .
Research on ZCCHC17 and other ZCCHC-containing proteins is ongoing, with studies focusing on their roles in RNA metabolism and their potential implications in diseases, including cancer. The recombinant form of ZCCHC17 is used in various research applications to study its structure, function, and interactions with other molecules.
