YWHAQ Antibody

Tyr-3/Trp-5 Monooxygenase Activation Protein Theta, also known as 14-3-3 theta or YWHAQ, is a member of the 14-3-3 protein family. These proteins are highly conserved and ubiquitously expressed in eukaryotic cells. They play crucial roles in various cellular processes, including signal transduction, cell cycle control, and apoptosis.

The 14-3-3 proteins, including the theta isoform, typically function as dimers. Each monomer consists of nine alpha-helices that form a cup-like structure. This structure allows the protein to bind to phosphorylated serine/threonine residues on target proteins, thereby modulating their function .

The primary function of 14-3-3 proteins is to mediate signal transduction by binding to phosphoserine-containing proteins. This binding can alter the conformation, activity, and localization of the target proteins. The 14-3-3 theta isoform, in particular, has been implicated in the regulation of various signaling pathways, including those involved in cell proliferation, differentiation, and apoptosis .

The 14-3-3 theta protein has been associated with several diseases. For instance, it is upregulated in patients with amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder that affects motor neurons . Additionally, the protein has been implicated in the progression of non-small cell lung cancer (NSCLC). Studies have shown that the miR-185-5p/YWHAZ axis plays a role in regulating NSCLC cell proliferation, migration, and apoptosis .

Mouse anti-human antibodies targeting Tyr-3/Trp-5 Monooxygenase Activation Protein Theta are widely used in research. These antibodies are valuable tools for studying the protein’s function and its role in various diseases. They can be used in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry to detect and quantify the protein in different biological samples .