YIF1B Human

YIF1B is a protein-coding gene that plays a significant role in the endoplasmic reticulum (ER) to Golgi vesicle-mediated transport . It is part of the FinGER protein family and is essential for the proper organization of the ER and Golgi apparatus . The protein is located in the Golgi apparatus, endoplasmic reticulum, and the ER-Golgi intermediate compartment .

YIF1B is involved in multiple cellular functions, including:

• Endoplasmic Reticulum to Golgi Transport: It facilitates the transport of proteins from the ER to the Golgi apparatus, which is crucial for protein processing and sorting .
• Membrane Trafficking: YIF1B plays a role in the trafficking of membrane proteins, including serotonin receptors (HTR), which are important for signal transmission in neuropathy .
• Sperm Axoneme Assembly: It is predicted to be involved in the assembly of the sperm axoneme, a structure critical for sperm motility .

Mutations or dysregulation of the YIF1B gene have been associated with several diseases, including:

• Kaya-Barakat-Masson Syndrome: A rare genetic disorder characterized by intellectual disability and other developmental issues .
• Autosomal Recessive Non-Syndromic Intellectual Disability: Another condition linked to mutations in the YIF1B gene .

Recent studies have highlighted the potential role of YIF1B in cancer biology. For instance, YIF1B expression has been found to be elevated in various cancer types, and its high expression is associated with poor overall survival and disease progression . This makes YIF1B a potential biomarker for prognostic and therapeutic evaluation in cancer treatment .