XAGE1A Human
X Antigen Family, Member 1A Human Recombinant
Cat. No.
BT1088
Source
Escherichia Coli.
Synonyms
X antigen family member 1, XAGE-1, Cancer/testis antigen 12.1, CT12.1, G antigen family D member 2, XAGE1A, GAGED2, XAGE1, CTP9, CT12.1C.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
XAGE1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 104 amino acids (1-81 a.a) and having a molecular mass of 11.5kDa.
XAGE1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
XAGE1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
G antigen family D member 2 (XAGE1A), part of the GAGE family, belongs to the XAGE subfamily. GAGE genes are expressed in various tumors and some fetal and reproductive tissues. XAGE1A, with a nuclear localization signal, shares sequence similarity with other GAGE/PAGE proteins. Its strong expression in Ewing's sarcoma, alveolar rhabdomyosarcoma, and normal testis, along with its sequence similarity, classifies XAGE1A as a cancer-testis (CT) antigen.
Description
Recombinant human XAGE1A, produced in E. coli, is a non-glycosylated polypeptide chain consisting of 104 amino acids (residues 1-81). It has a molecular weight of 11.5 kDa. The protein includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The XAGE1A protein solution is provided at a concentration of 0.25 mg/ml and contains 20 mM Tris-HCl buffer (pH 8.0), 200 mM NaCl, 20% glycerol, and 2 mM DTT.
Stability
For short-term storage (up to 2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is determined to be greater than 85% using SDS-PAGE analysis.
Synonyms
X antigen family member 1, XAGE-1, Cancer/testis antigen 12.1, CT12.1, G antigen family D member 2, XAGE1A, GAGED2, XAGE1, CTP9, CT12.1C.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMESPKKK NQQLKVGILH LGSRQKKIRI QLRSQCATWK VICKSCISQT PGINLDLGSG VKVKIIPKEE HCKMPEAGEE QPQV.
Product Science Overview
Gene Characteristics
Expression and Function
XAGE1A is strongly expressed in several types of cancers, including Ewing’s sarcoma, alveolar rhabdomyosarcoma, and normal testis . The protein encoded by this gene contains a nuclear localization signal and shares sequence similarity with other GAGE/PAGE proteins. Due to its expression pattern and sequence similarity, XAGE1A is classified as a cancer-testis (CT) antigen .
Alternative Splicing
Clinical Relevance
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