WNT7A Human
Description
WNT7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The WNT gene family is known for its role in the Wnt signaling pathway, which is essential for regulating cell fate, proliferation, migration, and patterning during embryonic development. WNT7A, in particular, functions as a ligand for members of the frizzled family of seven transmembrane receptors, operating within the canonical Wnt/β-catenin signaling pathway . This pathway is vital for numerous developmental processes, including dorsal-ventral patterning during limb development, skeleton development, and urogenital tract development .
WNT7A is involved in the development of the anterior-posterior axis in the female reproductive tract and plays a critical role in uterine smooth muscle patterning and maintenance of adult uterine function . Mutations in the WNT7A gene are associated with several congenital disorders, such as Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes . These conditions are characterized by limb malformations and other developmental abnormalities.
Research on WNT7A has shown its potential in targeting Wnt signaling to block angiogenesis and glucose uptake in brain tumors . This highlights the therapeutic potential of modulating Wnt signaling pathways in cancer treatment. Additionally, recombinant WNT7A proteins are used in various research applications to study their role in development and disease.
