VWA2 Human

Von Willebrand Factor A Domain Containing 2 Human Recombinant
Cat. No.
BT30248
Source

Escherichia Coli.

Synonyms

A domain-containing protein similar to matrilin and collagen, AMACO, Colon cancer secreted protein 2, CCSP-2.

Appearance

Sterile Filtered colorless liquid formulation.

Purity

Greater than 95% as determined by SDS-PAGE.

Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

VWA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 177 amino acids (341-517 a.a) and having a molecular mass of 19.3kDa.
The VWA2 is expressed with an amino-terminal hexahistidine tag and purified by proprietary chromatographic techniques.

Product Specs

Introduction
Von Willebrand Factor A Domain Containing 2 (VWA2) is an extracellular matrix protein that plays a role in cell adhesion and signaling. It features several vWA-like domains, known for their involvement in protein-protein interactions. VWA2's structure includes a signal peptide, three tandem vWA domains connected by a cysteine-rich sequence, and two EGF-like domains. Elevated VWA2 expression is observed in colon cancer and adenomas, suggesting its potential as a biomarker for early detection.
Description
Recombinant VWA2 protein, produced in E. coli, is a single, non-glycosylated polypeptide chain encompassing amino acids 341-517. This specific region of the VWA2 protein has a molecular mass of 19.3 kDa. The protein is purified using proprietary chromatographic techniques and includes an amino-terminal hexahistidine tag to facilitate purification and detection.
Physical Appearance
Sterile, colorless liquid.
Formulation
The VWA2 protein is supplied in a solution containing 20mM Tris-HCl (pH 8.0), 0.8M Urea, and 50% glycerol.
Stability
For short-term storage (up to 4 weeks), keep at 4°C. For long-term storage, freeze at -20°C. Avoid repeated freeze-thaw cycles to maintain protein stability.
Purity
Purity is greater than 95% as assessed by SDS-PAGE.
Synonyms

A domain-containing protein similar to matrilin and collagen, AMACO, Colon cancer secreted protein 2, CCSP-2.

Source

Escherichia Coli.

Product Science Overview

Introduction

Von Willebrand Factor A Domain Containing 2 (VWA2) is a protein encoded by the VWA2 gene. This protein is part of the von Willebrand factor A-like domain protein superfamily, which plays a crucial role in various biological processes, including cell adhesion, migration, and signal transduction .

Structure and Function

The VWA2 protein is characterized by the presence of the von Willebrand factor type A (vWA) domain. This domain is named after its occurrence in von Willebrand factor (vWF), a large multimeric glycoprotein found in blood plasma. The vWA domain is involved in binding to other proteins and is essential for the structural integrity of the extracellular matrix .

Biological Role

VWA2 is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. It has been linked to several biological functions, including calcium ion binding and identical protein binding .

Clinical Significance

Mutations in the VWA2 gene have been associated with various diseases, including vesicoureteral reflux and Charcot-Marie-Tooth disease, axonal type 2K. Additionally, VWA2 is considered a candidate serological marker for colon cancer .

Research and Applications

Human recombinant VWA2 is used in research to study its role in the extracellular matrix and its potential implications in various diseases. The recombinant form allows for controlled studies and the development of potential therapeutic applications.

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THE BIOTEK
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