VSTM2L Human

V-Set and Transmembrane Domain Containing 2 Like Human Recombinant

Cat. No.

BT29895

Source

E.coli.

Synonyms

V-set and transmembrane domain-containing protein 2-like protein, VSTM2L, C20orf102, dJ1118M15.2.

Appearance

Sterile Filtered colorless solution.

Purity

Greater than 90% as determined by SDS-PAGE.

Usage

THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

VSTM2L Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 205 amino acids (25-204 a.a.) and having a molecular mass of 22.6kDa.
VSTM2L is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction

VSTM2L (V-set and transmembrane domain containing 2) is a protein that has been identified as a regulator of the neuroprotective effects of HN. It is found in the brain, where it co-localizes with HN in specific regions and in primary neuronal cultures. VSTM2L has been shown to modulate neuronal survival and acts as a strong inhibitor of HN's neuroprotective activity in assays. As the first identified secreted antagonist of HN, VSTM2L may be important in controlling HN's biological actions.

Description

Recombinant human VSTM2L, produced in E. coli, is a single, non-glycosylated polypeptide chain that is 205 amino acids long (25-204 a.a.) and has a molecular weight of 22.6 kDa. A 25 amino acid His-tag is fused to the N-terminus of VSTM2L, which is then purified using proprietary chromatographic methods.

Physical Appearance

A clear, sterile solution.

Formulation

VSTM2L protein solution (0.25 mg/ml) in 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 0.1M NaCl, 1mM DTT, and 0.1mM PMSF.

Stability

The product should be stored at 4°C if it will be used within 2-4 weeks. For longer-term storage, it is recommended to freeze the product at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Multiple freeze-thaw cycles should be avoided.

Purity

The purity of the product is greater than 90% as determined by SDS-PAGE analysis.

Synonyms

V-set and transmembrane domain-containing protein 2-like protein, VSTM2L, C20orf102, dJ1118M15.2.

Source

E.coli.

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTRPAG HAPWDNHVSG HALFTETPHD MTARTGEDVE MACSFRGSGS PSYSLEIQWW YVRSHRDWTD KQAWASNQLK ASQQEDAGKE ATKISVVKVV GSNISHKLRL SRVKPTDEGS YECRVIDFSD GKARHHKVKA YLRVQPGENS VLHLPEAPPA APAPPPPKPG KELRKRSVDQ EACSL.

Product Science Overview

Gene and Protein Structure

VSTM2L is located on chromosome 20 and encodes a 22 kDa extracellular protein. The protein contains an N-terminal signal peptide and an immunoglobulin-like domain with a disulfide bond between specific cysteine residues. This structure is crucial for its function in cell-cell adhesion and interaction.

Function and Biological Role

VSTM2L is predicted to enable cell-cell adhesion mediator activity and is involved in the negative regulation of neuron apoptotic processes. This means that it plays a role in preventing the programmed cell death of neurons, which is essential for maintaining healthy neural networks.

Clinical Significance

Diseases associated with VSTM2L include Bietti Crystalline Corneoretinal Dystrophy, a rare genetic eye disorder. The gene’s role in cell adhesion and neuron survival suggests it could be significant in various neurological conditions, although more research is needed to fully understand its implications.

Research and Applications

VSTM2L is a subject of interest in various research fields, including neuroscience and immunology. Recombinant forms of this protein are used in laboratory settings to study its function and potential therapeutic applications. For instance, ELISA kits are available to quantify VSTM2L in biological samples, which helps in understanding its expression patterns and role in different tissues.

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VSTM2L Human

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Product Specs

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