VSNL1 Human
Description
The VSNL1 is purified by proprietary chromatographic techniques.
Product Specs
VSNL1, also known as VILIP1, is a member of the visinin/recoverin family of neuronal calcium sensor proteins. It is highly expressed in cerebellar granule cells, where it exhibits calcium-dependent membrane association and plays a role in modulating intracellular signaling pathways within the central nervous system. VSNL1 is involved in regulating adenylyl cyclase activity directly or indirectly. Studies have shown altered VSNL1 expression in the hippocampus of individuals with schizophrenia, with increased immunoreactivity observed in interneurons. Furthermore, VSNL1 is expressed in pancreatic beta-cells and interacts with both the cell membrane and the actin-based cytoskeleton. Notably, it has been found to influence cAMP accumulation in C6 glioma cells, while HLP3, another protein, modulates cGMP accumulation in transfected neural cells and cerebellar granule neurons.
Product Science Overview
VILIP-1 is a calcium-binding protein that plays a crucial role in regulating neuronal growth, survival, and synaptic plasticity . It associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways by directly or indirectly regulating the activity of adenylyl cyclase . This protein is involved in various biological processes, including:
VILIP-1 has emerged as a potential biomarker for neurodegenerative diseases, particularly Alzheimer’s disease (AD) . Elevated levels of VILIP-1 in cerebrospinal fluid (CSF) and serum have been associated with early stages of AD and other conditions like Creutzfeldt-Jakob disease (CJD) . The analysis of VILIP-1 levels in CSF and serum can aid in the differential diagnosis of these diseases .
Recent studies have focused on developing sensitive assays for detecting VILIP-1 in CSF and serum. One such assay is the single molecule array (Simoa) assay, which has shown promise in the early diagnosis of AD . Additionally, VILIP-1 is being studied as a marker for neuronal injury in stroke, traumatic brain injuries, and other neurodegenerative conditions .
