VIP
Vasoactive Intestinal Peptide
Cat. No.
BT23930
Source
Synonyms
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 97.0% as determined by analysis by RP-HPLC.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Vasoactive Intestinal Peptide Synthetic is a single, non-glycosylated polypeptide chain containing 28 amino acids, having a molecular mass of 3325 Dalton and a Molecular formula of C147H238N44O42S .
Product Specs
Description
Vasoactive Intestinal Peptide Synthetic is a single, non-glycosylated polypeptide chain containing 28 amino acids with a molecular mass of 3325 Daltons and a molecular formula of C147H238N44O42S.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
The protein was lyophilized with no additives.
Solubility
Reconstitute the lyophilized Vasoactive Intestinal Peptide in sterile 18MΩ-cm H2O at a concentration not less than 100 µg/ml. This solution can be further diluted to other aqueous solutions.
Stability
Lyophilized Vasoactive Intestinal Peptide is stable at room temperature for 3 weeks but should be stored desiccated below -18°C. Upon reconstitution, Vasoactive Intestinal Peptide should be stored at 4°C for 2-7 days. For future use, store below -18°C. For long term storage, add a carrier protein (0.1% HSA or BSA). Avoid freeze-thaw cycles.
Purity
Greater than 97.0% as determined by RP-HPLC analysis.
Amino Acid Sequence
H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2.
Product Science Overview
Discovery and Structure
Expression and Distribution
Functions
VIP has a wide range of physiological functions:
- Cardiovascular System: It stimulates contractility in the heart and causes vasodilation, which helps lower arterial blood pressure .
- Digestive System: VIP increases glycogenolysis and relaxes the smooth muscle of the trachea, stomach, and gallbladder . It also stimulates the secretion of electrolytes and water by the intestinal mucosa .
- Nervous System: VIP functions as a neuromodulator and neurotransmitter. It regulates smooth muscle activity, epithelial cell secretion, and blood flow in the gastrointestinal tract .
Receptors and Signal Transduction
Clinical Significance
VIP has been studied for its potential therapeutic applications due to its vasodilatory and anti-inflammatory properties. It is also involved in the regulation of immune responses and has been implicated in various diseases, including asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD) .
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