UXT Human

The Ubiquitously-Expressed, Prefoldin-Like Chaperone, also known as UXT, is a protein encoded by the UXT gene. This protein plays a crucial role in various cellular processes, including gene transcription regulation and apoptosis. It is involved in the modulation of androgen receptor-dependent transcription and tumor necrosis factor-induced apoptosis .

The UXT gene is a protein-coding gene associated with several diseases, including Amyotrophic Lateral Sclerosis 1 and Retinitis Pigmentosa . The protein encoded by this gene has multiple isoforms due to alternatively spliced transcript variants . UXT is known for its chromatin binding and actin filament binding properties .

UXT functions as a cofactor that modulates androgen receptor-dependent transcription. It plays a critical role in tumor necrosis factor-induced apoptosis, which is essential for maintaining cellular homeostasis and preventing tumorigenesis . Additionally, UXT acts as a nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome, thereby positively regulating NF-kappa-B transcription activity .

UXT works in concert with the corepressor URI1 to regulate androgen receptor-mediated transcription. Together, they associate with chromatin to the NKX3-1 promoter region . UXT also negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm . Furthermore, UXT is a potential component of mitochondrial-associated LRPPRC, which integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling .

Recombinant human UXT is available for research purposes. It is typically provided in a solution containing Tris-HCl buffer, urea, and glycerol . This recombinant protein is used in various biochemical assays to study its functions and mechanisms in detail.