UTP23 Human
UTP23, Small Subunit Processome Component Human Recombinant
Cat. No.
BT28818
Source
E.coli.
Synonyms
UTP23 Small Subunit (SSU) Processome Component, Homolog (Yeast), Chromosome 8 Open Reading Frame 53, RRNA-Processing Protein UTP23 Homolog, MGC14595, C8orf53.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
UTP23 Human Recombinant produced in E. coli is a single polypeptide chain containing 272 amino acids (1-249) and having a molecular mass of 30.8 kDa.
UTP23 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
UTP23 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
The protein encoded by UTP23 is a component of the small subunit (SSU) processome, which is crucial for ribosome biogenesis. The SSU processome is responsible for the maturation of pre-18S rRNA. Within this complex, UTP23 plays a vital role in the initial three cleavage steps of 18S rRNA maturation. Notably, while single-point mutations in the conserved putative active site of Utp24 completely abolish its function in ribosome biogenesis, similar mutations in Utp23 do not have the same effect.
Description
Recombinant human UTP23, expressed in E. coli, is a single polypeptide chain with a molecular weight of 30.8 kDa. This protein comprises 272 amino acids, including a 23 amino acid His-tag fused to the N-terminus (amino acids 1-249). Purification is achieved using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
The UTP23 solution is formulated in 20mM Tris-HCl buffer with a pH of 8.0, 0.2M NaCl, 1mM DTT, and 20% glycerol.
Stability
For short-term storage (2-4 weeks), the UTP23 solution should be stored at 4°C. For longer storage, it is recommended to freeze the solution at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage. To maintain protein integrity, avoid repeated cycles of freezing and thawing.
Purity
Purity of UTP23 is greater than 90% as determined by SDS-PAGE analysis.
Synonyms
UTP23 Small Subunit (SSU) Processome Component, Homolog (Yeast), Chromosome 8 Open Reading Frame 53, RRNA-Processing Protein UTP23 Homolog, MGC14595, C8orf53.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMKITRQK HAKKHLGFFR NNFGVREPYQ ILLDGTFCQA ALRGRIQLRE QLPRYLMGET QLCTTRCVLK ELETLGKDLY GAKLIAQKCQ VRNCPHFKNA VSGSECLLSM VEEGNPHHYF VATQDQNLSV KVKKKPGVPL MFIIQNTMVL DKPSPKTIAF VKAVESGQLV SVHEKESIKH LKEEQGLVKN TEQSRRKKRK KISGPNPLSC LKKKKKAPDT QSSASEKKRK RKRIRNRSNP KVLSEKQNAE GE
Product Science Overview
Gene and Protein Information
- Gene Name: UTP23 (also known as C8orf53, MGC14595)
- Protein Name: UTP23 Small Subunit Processome Component
- Chromosomal Location: Chromosome 8
- Protein Class: Protein Coding Gene
- UniProtKB/Swiss-Prot ID: Q9BRU9
Function and Mechanism
The UTP23 protein is predicted to be involved in several key processes:
- rRNA Processing: It plays a role in the processing of ribosomal RNA (rRNA), which is a critical component of ribosome biogenesis .
- Ribosome Biogenesis: UTP23 is essential for the formation of the 40S ribosomal subunit, a component of the small ribosomal subunit .
- RNA Binding: It has mRNA 3’-UTR and 5’-UTR binding activities, indicating its involvement in RNA metabolism .
Biological Significance
UTP23 is implicated in various biological processes and diseases:
Expression and Localization
Research and Clinical Relevance
The study of UTP23 is significant for understanding ribosome biogenesis and its implications in human diseases. Research on UTP23 can provide insights into the molecular mechanisms underlying ribosomal disorders and cancer. Additionally, recombinant UTP23 protein can be used in various experimental setups to study its function and interactions.
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