UNC5B Rat
HEK293.
unc-5 netrin receptor B, Unc5h2, unc-5 homolog 2, Protein unc-5 homolog B, netrin receptor UNC5B precursor, netrin receptor UNC5B, protein unc-5 homolog 2, unc5b.
Greater than 90.0% as determined by SDS-PAGE.
Description
UNC5B Rat Recombinant produced in HEK293 is a single, non-glycosylated polypeptide chain containing 590 amino acids (27-373 a.a) and having a molecular mass of 66.0kDa. UNC5B is fused to a 243 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
unc-5 netrin receptor B, Unc5h2, unc-5 homolog 2, Protein unc-5 homolog B, netrin receptor UNC5B precursor, netrin receptor UNC5B, protein unc-5 homolog 2, unc5b.
HEK293.
DGSMGIDSGG QALPDSFPSA PAEQLPHFLL EPEDAYIVKN KPVELHCRAF PATQIYFKCN GEWVSQKGHV TQESLDEATG LRIREVQIEV SRQQVEELFG LEDYWCQCVA WSSSGTTKSR RAYIRIAYLR KNFDQEPLAK EVPLDHEVLL QCRPPEGVPV AEVEWLKNED VIDPAQDTNF LLTIDHNLII RQARLSDTAN YTCVAKNIVA KRRSTTATVI VYVNGGWSSW AEWSPCSNRC GRGWQKRTRT CTNPAPLNGG AFCEGQACQK TACTTVCPVD GAWTEWSKWS ACSTECAHWR SRECMAPPPQ NGGRDCSGTL LDSKNCTDGL CVLNQRTLND PKSRPLEPSG DVEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH.
Product Science Overview
UNC-5 Netrin Receptor B (UNC5B) is a protein that belongs to the UNC5 family, which includes four related receptors. These receptors play a crucial role in axon guidance by acting as receptors for the axon guidance molecule, Netrin-1 . UNC5B is particularly significant in various biological processes, including leukocyte migration, capillary branching, and osteoclast differentiation, all of which are mediated by Netrin-1 .
The recombinant rat UNC5B protein is produced in HEK293 cells and is a single, non-glycosylated polypeptide chain containing 590 amino acids (27-373 a.a) with a molecular mass of approximately 66.0 kDa . The protein is fused to a 243 amino acid hIgG-His-tag at the C-terminus and is purified using proprietary chromatographic techniques .
UNC5B plays a vital role in several biological processes:
- Axon Guidance: As a receptor for Netrin-1, UNC5B is involved in guiding axons to their correct destinations during neural development .
- Leukocyte Migration: UNC5B inhibits leukocyte migration, which is essential for immune response regulation .
- Capillary Branching: It promotes capillary branching, contributing to the formation of new blood vessels .
- Osteoclast Differentiation: UNC5B is involved in the differentiation of osteoclasts, which are cells responsible for bone resorption .
UNC5B is implicated in various pathological conditions:
- Apoptosis: UNC5B is responsible for the activation of DAPK1, which can induce apoptosis .
- Tumorigenesis: It plays a role in the development of tumors .
- Atherosclerosis: UNC5B is involved in the development of atherosclerosis .
- Kidney Injury: It contributes to the survival of tubular epithelial cells during acute kidney injury .
