UBTD2 Human

Ubiquitin Domain Containing 2 Human Recombinant
Cat. No.
BT28036
Source
E.coli.
Synonyms
Ubiquitin domain containing protein 2, Dendritic cell-derived ubiquitin-like protein, Ubiquitin-like protein SB72, DCUBP, MGC30022.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

UBTD2 Human Recombinant produced in E. coli is a single polypeptide chain containing 257 amino acids (1-234) and having a molecular mass of 28.6 kDa.
UBTD2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
UBTD2, an ubiquitin (Ub) domain-containing protein found in dendritic cells, plays a role in the ubiquitination pathway. While ubiquitin is a well-known post-translation modifier, a growing family of ubiquitin-like proteins (UBLs) modify cellular targets through a specific pathway. These UBLs are involved in various cellular processes, including DNA repair, protein sorting and degradation, cell division, apoptosis, and autophagy.
Description
Recombinant human UBTD2, produced in E. coli, is a single polypeptide chain consisting of 257 amino acids (residues 1-234). It has a molecular weight of 28.6 kDa. This protein includes a 23 amino acid His-tag fused to its N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, sterile solution.
Formulation
The UBTD2 solution is provided at a concentration of 0.5 mg/ml and contains 20 mM Tris-HCl buffer (pH 8.0), 100 mM NaCl, 1 mM DTT, and 20% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For long-term storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for extended storage. Avoid repeated freezing and thawing.
Purity
Purity is greater than 95% as assessed by SDS-PAGE.
Synonyms
Ubiquitin domain containing protein 2, Dendritic cell-derived ubiquitin-like protein, Ubiquitin-like protein SB72, DCUBP, MGC30022.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGGCVGA QHDSSGSLNE NSEGTGVALG RNQPLKKEKP KWKSDYPMTD GQLRSKRDEF WDTAPAFEGR KEIWDALKAA AHAFESNDHE LAQAIIDGAN ITLPHGALTE CYDELGNRYQ LPVYCLAPPI NMIEEKSDIE TLDIPEPPPN SGYECQLRLR LSTGKDLKLV VRSTDTVFHM KRRLHAAEGV EPGSQRWFFS GRPLTDKMKF EELKIPKDYV VQVIVSQPVQ NPTPVEN

Product Science Overview

Introduction

Ubiquitin Domain Containing 2 (UBD2) is a protein that plays a crucial role in the ubiquitin-proteasome system, which is responsible for the degradation of most intracellular proteins. This system is essential for maintaining cellular homeostasis and regulating various cellular processes, including cell cycle progression, DNA repair, and response to oxidative stress.

Structure and Function

UBD2 contains a ubiquitin-like domain, which allows it to interact with other proteins involved in the ubiquitination process. Ubiquitination is a post-translational modification where ubiquitin, a small regulatory protein, is attached to a substrate protein. This process typically marks the substrate for degradation by the proteasome, a large protein complex that breaks down unneeded or damaged proteins .

Biological Significance

The ubiquitin-proteasome system, including proteins like UBD2, is vital for numerous cellular functions. It regulates the turnover of proteins, ensuring that damaged or misfolded proteins are promptly degraded. This system also controls the levels of various regulatory proteins, thereby influencing cell cycle progression, apoptosis, and other critical cellular processes .

Recombinant UBD2

Recombinant UBD2 refers to the UBD2 protein that has been produced using recombinant DNA technology. This involves inserting the gene encoding UBD2 into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities. Recombinant proteins are widely used in research and therapeutic applications due to their high purity and consistency .

Applications in Research and Medicine

Recombinant UBD2 is used in various research applications to study the ubiquitin-proteasome system and its role in cellular processes. It is also used to investigate the mechanisms of diseases associated with dysregulation of protein degradation, such as cancer and neurodegenerative disorders. Additionally, recombinant UBD2 can be used in drug discovery to screen for compounds that modulate the ubiquitin-proteasome system .

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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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