TYRO3 Mouse
Etk2/tyro3, TK19-2, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF, Tyro3, Dtk, Rse, Tif, AI323366, Brt, Etk-2.
Greater than 95.0% as determined by SDS-PAGE.
Description
TYRO3 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 628 amino acids (31-419 aa) and having a molecular mass of 68.9kDa.
TYRO3 is fused to a 239 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
Etk2/tyro3, TK19-2, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF, Tyro3, Dtk, Rse, Tif, AI323366, Brt, Etk-2.
AGLKLMGAPV KMTVSQGQPV KLNCSVEGME DPDIHWMKDG TVVQNASQVS ISISEHSWIG LLSLKSVERS DAGLYWCQVK DGEETKISQS VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IYWWRGLTKV GGPAPSPSVL NVTGVTQRTE FSCEARNIKG LATSRPAIVR LQAPPAAPFN TTVTTISSYN ASVAWVPGAD GLALLHSCTV QVAHAPGEWE ALAVVVPVPP FTCLLRNLAP ATNYSLRVRC ANALGPSPYG DWVPFQTKGL APARAPQNFH AIRTDSGLIL EWEEVIPEDP GEGPLGPYKL SWVQENGTQD ELMVEGTRAN LTDWDPQKDL ILRVCASNAI GDGPWSQPLV VSSHDHAGRQ GPPHSRTSWL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH
Product Science Overview
TYRO3 Protein Tyrosine Kinase, also known as TYRO3, is a member of the TAM (TYRO3, AXL, and MERTK) family of receptor tyrosine kinases. These receptors play crucial roles in various physiological processes, including cell survival, migration, differentiation, and immune regulation . TYRO3 is particularly significant in the context of its involvement in the regulation of cell survival and proliferation, spermatogenesis, immunoregulation, and phagocytosis .
TYRO3 is a transmembrane receptor tyrosine kinase characterized by an extracellular region with two immunoglobulin-like (Ig-like) domains, followed by two fibronectin type III (FNIII) domains, a single transmembrane region, and a cytoplasmic tyrosine kinase domain . Upon ligand binding, TYRO3 undergoes dimerization and autophosphorylation on its intracellular domain, creating docking sites for downstream signaling molecules . This activation leads to the enhancement of PI3-kinase activity and the activation of the AKT survival pathway .
TYRO3 is involved in several critical physiological processes:
- Cell Survival and Proliferation: TYRO3 activation promotes cell survival and proliferation through the PI3K/AKT signaling pathway .
- Spermatogenesis: TYRO3 plays a role in the regulation of spermatogenesis, ensuring the proper development and function of sperm cells .
- Immunoregulation: TYRO3 is involved in the regulation of immune responses, helping to maintain immune homeostasis and prevent excessive inflammation .
- Phagocytosis: TYRO3 is essential for the process of phagocytosis, where cells engulf and digest cellular debris and pathogens .
Mutations or dysregulation of TYRO3 have been associated with various diseases, including lymphocytic choriomeningitis and progressive non-fluent aphasia . Additionally, TYRO3 has been identified as a cell entry factor for Ebola and Marburg viruses, highlighting its significance in viral pathogenesis .
