TUSC2 Human
Tumor Suppressor Candidate 2 Human Recombinant
Cat. No.
BT27565
Source
Escherichia Coli.
Synonyms
Tumor suppressor candidate 2, C3orf11, FUS1, PAP, PDAP2, TUSC2,
Fusion 1 protein, Fus-1 protein, PDGFA-associated protein 2, LGCC.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
TUSC2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (1-110) and having a molecular mass of 14.5 kDa.
TUSC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TUSC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Tumor Suppressor Candidate 2 (TUSC2), a member of the TUSC2 family, acts as a tumor suppressor. It inhibits colony formation, induces G1 arrest, and ultimately leads to apoptosis in cells lacking the homozygous 3p21.3 120-kb region.
Description
Recombinant human TUSC2, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 133 amino acids (residues 1-110) with a molecular weight of 14.5 kDa. This protein is fused to a 23-amino acid His-tag at the N-terminus and purified using proprietary chromatographic methods.
Physical Appearance
Clear, colorless solution, sterilized by filtration.
Formulation
The TUSC2 solution is provided at a concentration of 0.5 mg/ml in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.4 M urea, and 10% glycerol.
Stability
For short-term storage (up to 2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Minimize repeated freeze-thaw cycles.
Purity
Purity is greater than 95.0% as determined by SDS-PAGE analysis.
Synonyms
Tumor suppressor candidate 2, C3orf11, FUS1, PAP, PDAP2, TUSC2,
Fusion 1 protein, Fus-1 protein, PDGFA-associated protein 2, LGCC.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGASGSK ARGLWPFASA AGGGGSEAAG AEQALVRPRG RAVPPFVFTR RGSMFYDEDG DLAHEFYEET IVTKNGQKRA KLRRVHKNLI PQGIVKLDHP RIHVDFPVIL YEV.
Product Science Overview
Discovery and Initial Research
TUSC2 was discovered during studies aimed at identifying genes located in regions of the genome that are often deleted in cancer cells. The 3p21.3 region, where TUSC2 resides, is one such hotspot for deletions in various cancers, including lung, breast, ovarian, and thyroid cancers . Early research demonstrated that re-expression of TUSC2 in cancer cells could inhibit their growth and induce apoptosis, highlighting its potential role as a tumor suppressor .
Biological Functions
TUSC2 plays several critical roles in normal cellular functions:
- Regulation of Mitochondrial Calcium Movement: TUSC2 is involved in the regulation of calcium movement within cells and mitochondria, which is crucial for maintaining cellular homeostasis .
- Immune System Regulation: TUSC2 helps regulate the immune system and prevents the development of autoimmune diseases .
- Premature Aging: Loss of TUSC2 has been linked to premature aging, including conditions such as hearing loss and sporadic Alzheimer’s disease .
Mechanisms of Tumor Suppression
TUSC2 exerts its tumor-suppressive effects through various mechanisms:
- Induction of Apoptosis: TUSC2 can induce apoptosis in cancer cells, thereby inhibiting their growth .
- G1 Cell Cycle Arrest: TUSC2 can cause G1 cell cycle arrest, preventing cancer cells from proliferating .
- Inhibition of Colony Formation: TUSC2 inhibits the ability of cancer cells to form colonies, which is a key step in tumor development .
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