TTR Antibody
Transthyretin, Mouse Anti Human
Cat. No.
BT2216
Source
Synonyms
Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB, HsT2651.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Product Specs
Introduction
Transthyretin (TTR) is a circulating and abundant tetramer that serves as a carrier protein for thyroid hormone and retinol binding protein. Primarily produced in the liver, and to a lesser extent in the brain and eye, TTR plays a crucial role in hormone transport. Mutations in the TTR gene can disrupt the protein's structure, causing it to dissociate into monomers. These monomers then misfold and aggregate, forming amyloid fibrils that deposit in various organs. Notably, TTR is the only gene currently known to be associated with familial TTR amyloidosis. Diseases arising from mutations in the TTR gene include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome.
Physical Appearance
Sterile filtered colorless solution.
Formulation
1mg/ml in PBS, pH 7.4, with 0.1% Sodium Azide.
Storage Procedures
Store at 4°C for up to 1 month. For longer-term storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Stability / Shelf Life
Stable for 12 months at -20°C and 1 month at 4°C.
Applications
TTR antibody has undergone rigorous testing by ELISA and Western blot analysis to ensure its specificity and reactivity. However, optimal working dilutions may vary depending on the specific application. For Western blot analysis, a dilution range of 1:500 to 1:3000 is recommended, with a starting dilution of 1:500.
Synonyms
Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB, HsT2651.
Purification Method
TTR antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT7B2AT.
Immunogen
Anti-human TTR mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TTR amino acids 21-147 purified from E. coli.
Ig Subclass
Mouse IgG1 heavy chain and κ light chain.
Product Science Overview
Transthyretin (TTR)
Transthyretin (TTR), also known as prealbumin, is a protein primarily synthesized in the liver and choroid plexus of the brain. It functions as a transport protein for thyroxine (T4) and retinol (vitamin A) by forming a complex with retinol-binding protein . TTR is a homo-tetrameric protein, meaning it consists of four identical subunits .
Biological Role and Importance
TTR plays a crucial role in the transport of thyroid hormones and vitamin A, which are essential for various physiological processes, including metabolism, growth, and development . Additionally, TTR is involved in other intracellular processes such as proteolysis, nerve regeneration, autophagy, and glucose homeostasis .
Clinical Significance
Mouse Anti-Human Transthyretin Antibodies
Applications
Mouse anti-human transthyretin antibodies are used in several scientific applications, including:
- Western Blot (WB): To detect and quantify TTR protein levels in samples.
- Immunohistochemistry (IHC): To visualize TTR distribution in tissue sections.
- Immunocytochemistry (ICC): To study TTR localization in cultured cells.
- Enzyme-Linked Immunosorbent Assay (ELISA): To measure TTR concentrations in biological fluids .
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