Trp

Triptorelin acetate has a chemical formula of C64H82N18O13 and a molecular weight of approximately 1311.47 g/mol . It is a more potent analog of endogenous LHRH, meaning it has a stronger effect on the body compared to the naturally occurring hormone .

When administered, triptorelin initially causes a surge in the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a temporary increase in the production of sex hormones such as testosterone and estrogen . However, with continuous administration, triptorelin desensitizes the LHRH receptors in the pituitary gland, leading to a significant decrease in LH and FSH levels. This results in reduced production of sex hormones, effectively mimicking the effects of surgical castration in men and reducing estrogen levels in women .

Triptorelin acetate is primarily indicated for the palliative treatment of advanced prostate cancer . By reducing testosterone levels, it helps to slow the growth of prostate cancer cells. Additionally, it is used in the management of endometriosis and uterine fibroids by lowering estrogen levels, which can help alleviate symptoms and reduce the size of fibroids .

In some cases, triptorelin is also used off-label to delay puberty in children with gender dysphoria or other conditions that cause precocious puberty .

Triptorelin was first patented in 1975 and approved for medical use in 1986 . Since then, it has become an important tool in the management of hormone-sensitive conditions. It is available under various brand names, including Decapeptyl, Trelstar, and Triptodur .

Common side effects of triptorelin acetate include hot flashes, decreased libido, erectile dysfunction, and injection site reactions . Long-term use can lead to bone density loss, so patients may need to be monitored for osteoporosis . It is important for patients to discuss potential side effects and precautions with their healthcare provider before starting treatment.