TPT1 Mouse

Tumor Protein Translationally-Controlled 1 (TPT1), also known as Translationally Controlled Tumor Protein (TCTP), is a highly conserved protein found in eukaryotic cells. It was first discovered in 1989 as a cDNA sequence obtained from a human mammary carcinoma cDNA library . TPT1 is involved in various cellular processes, including cell growth, proliferation, and apoptosis.

The TPT1 gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5’-TOP) in its 5’ untranslated region, which functions to repress its translation under quiescent conditions . The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis, and cell division .

TPT1 plays a crucial role in several biological processes:

• Microtubule Stabilization: TPT1 binds to and stabilizes microtubules, which are essential for cell division .
• Apoptosis Regulation: It acts as a negative regulator of TSC22D1-mediated apoptosis by interacting with and destabilizing the TSC22D1 protein .
• Calcium Binding: TPT1 is involved in calcium binding, which is important for various cellular functions .

TPT1 is known to play a role in carcinogenesis and is upregulated in some cancer cells . Its involvement in cell growth and proliferation makes it a potential target for cancer therapy. Dysregulation of TPT1 levels can promote a range of disease processes, including cancer .

Research on TPT1 has expanded to various fields, including its role in plant biology. For instance, TPT1 has been studied for its interaction with SNF1-related protein kinase (SnRK1) in wheat, where it regulates cell division, plant growth, and resistance to pathogen infection .