TOM1L2 Human
Target of Myb1-Like 2 Human Recombinant
Cat. No.
BT25833
Source
Escherichia Coli.
Synonyms
TOM1-like protein 2, Target of Myb-like protein 2, TOM1L2.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 80.0% as
determined by SDS-PAGE.
Usage
THE BioTeks products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
TOM1L2 Human
Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain
containing 532 amino acids (1-507aa) and having a molecular mass of 58.2kDa.
TOM1L2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TOM1L2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Target of Myb1-Like 2, also known as TOM1L2, is a member of the TOM1 family. TOM1L2 participates in protein transport. Furthermore, TOM1L2 regulates growth factor-induced mitogenic signaling.
Description
TOM1L2 Human Recombinant is produced in E. coli. It is a single, non-glycosylated polypeptide chain containing 532 amino acids (1-507aa) and has a molecular mass of 58.2kDa. TOM1L2 is fused to a 25 amino acid His-tag at the N-terminus and purified by proprietary chromatographic techniques.
Physical Appearance
Sterile Filtered clear solution.
Formulation
TOM1L2 protein solution (0.5mg/ml) is supplied in Phosphate buffered saline (pH 7.4), 10% glycerol, and 1mM DTT.
Stability
The product should be stored at 4°C if the entire vial will be used within 2-4 weeks. For longer periods, it should be stored frozen at -20°C. For long term storage, adding a carrier protein (0.1% HSA or BSA) is recommended. Avoid multiple freeze-thaw cycles.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Synonyms
TOM1-like protein 2, Target of Myb-like protein 2, TOM1L2.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH
SSGLVPRGSH MGSEFMEFLL GNPFSTPVGQ CLEKATDGSL QSEDWTLNME ICDIINETEE
GPKDAIRALK KRLNGNRNYR EVMLALTVLE TCVKNCGHRF HILVANRDFI DSVLVKIISP KNNPPTIVQD
KVLALIQAWA DAFRSSPDLT GVVHIYEELK RKGVEFPMAD
LDALSPIHTP QRSVPEVDPA ATMPRSQSQQ RTSAGSYSSP PPAPYSAPQA PALSVTGPIT ANSEQIARLR SELDVVRGNT KVMSEMLTEM VPGQEDSSDL ELLQELNRTC RAMQQRIVEL ISRVSNEEVT EELLHVNDDL NNVFLRYERF ERYRSGRSVQ NASNGVLNEV TEDNLIDLGP GSPAVVSPMV GNTAPPSSLS SQLAGLDLGT ESVSGTLSSL QQCNPRDGFD MFAQTRGNSL AEQRKTVTYE DPQAVGGLAS ALDNRKQSSE GIPVAQPSVM DDIEVWLRTD LKGDDLEEGV TSEEFDKFLE ERAKAAEMVP DLPSPPMEAP APASNPSGRK KPERSEDALF AL.
LDALSPIHTP QRSVPEVDPA ATMPRSQSQQ RTSAGSYSSP PPAPYSAPQA PALSVTGPIT ANSEQIARLR SELDVVRGNT KVMSEMLTEM VPGQEDSSDL ELLQELNRTC RAMQQRIVEL ISRVSNEEVT EELLHVNDDL NNVFLRYERF ERYRSGRSVQ NASNGVLNEV TEDNLIDLGP GSPAVVSPMV GNTAPPSSLS SQLAGLDLGT ESVSGTLSSL QQCNPRDGFD MFAQTRGNSL AEQRKTVTYE DPQAVGGLAS ALDNRKQSSE GIPVAQPSVM DDIEVWLRTD LKGDDLEEGV TSEEFDKFLE ERAKAAEMVP DLPSPPMEAP APASNPSGRK KPERSEDALF AL.
Product Science Overview
Gene and Protein Structure
TOM1L2 is located on chromosome 17p11.2 . The gene encodes a protein that consists of 457 amino acids and has several important domains:
- N-terminal VHS domain: This domain is involved in vesicular trafficking.
- Central GAT domain: This domain is crucial for interactions with other proteins involved in endocytosis.
- C-terminal clathrin-binding motif: This motif allows the protein to interact with clathrin, a protein that plays a key role in the formation of coated vesicles.
Function and Mechanism
TOM1L2 is involved in the recruitment of clathrin onto endosomes, a process essential for endosomal sorting and trafficking . The protein interacts with several other proteins, including:
- TOLLIP: A protein involved in endosomal sorting.
- Clathrin heavy chain (CLTC): Essential for the formation of clathrin-coated vesicles.
These interactions suggest that TOM1L2 plays a significant role in modulating endosomal functions and ensuring proper vesicular trafficking within the cell .
Biological Significance
Research and Clinical Implications
Research on TOM1L2 has provided insights into its role in cellular processes and its potential implications in various diseases. Understanding the function and regulation of TOM1L2 can contribute to the development of therapeutic strategies for conditions associated with its dysfunction.
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