TMIGD2 Human
HEK293 Cells.
IGPR-1, IGPR1,TMIGD2, Transmembrane and immunoglobulin domain-containing protein 2 isoform1, CD28 homolog, CD28H, Immunoglobulin and proline-rich receptor 1.
Greater than 95.0% as determined by SDS-PAGE.
Description
TMIGD2 Human Recombinant is a single, glycosylated, polypeptide chain (23-150 a.a) containing a total of 361 amino acids and having a molecular mass of 40.1 kDa.
TMIGD2 is fused to a 233 a.a hIgG -Tag at C-terminus and is purified by proprietary chromatographic techniques.
Product Specs
IGPR-1, IGPR1,TMIGD2, Transmembrane and immunoglobulin domain-containing protein 2 isoform1, CD28 homolog, CD28H, Immunoglobulin and proline-rich receptor 1.
HEK293 Cells.
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LSVQQGPNLL QVRQGSQATL VCQVDQATAW ERLRVKWTKD GAILCQPYIT NGSLSLGVCG PQGRLSWQAP SHLTLQLDPV SLNHSGAYVC WAAVEIPELE EAEGNITRLF VDPDDPTQNR NRIASFPGLE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPGK. |
Product Science Overview
TMIGD2 is a transmembrane protein, meaning it spans the cell membrane and has both extracellular and intracellular domains . The extracellular domain contains immunoglobulin-like regions, which are important for its role in cell signaling and interactions . TMIGD2 is predominantly located in the plasma membrane and is also found in the extracellular space .
TMIGD2 is involved in several key biological processes:
- Cell-Cell Interaction: TMIGD2 enhances cell-cell interactions and aggregation, which is essential for maintaining tissue integrity and facilitating communication between cells .
- Cell Migration: It plays a role in cell migration, a process critical for wound healing, immune responses, and development .
- Angiogenesis: TMIGD2 positively regulates angiogenesis, the formation of new blood vessels from pre-existing ones, which is vital for tissue growth and repair .
TMIGD2 is expressed on T cells and natural killer (NK) cells, where it acts as a co-receptor . It interacts with HHLA2, a member of the B7 family of immune regulatory proteins, to co-stimulate T cells and NK cells . This interaction enhances T cell proliferation and cytokine production through an AKT-dependent signaling cascade . As a result, TMIGD2 plays a significant role in modulating immune responses and maintaining immune homeostasis.
