TMEFF1 Human

TMEFF1 Human Recombinant
Cat. No.
BT25292
Source
E.coli.
Synonyms
C9orf2, CT120.1, H7365, TR-1, Tomoregulin-1, Transmembrane protein with EGF-like and one follistatin-like domain, TMEFF1.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

TMEFF1 Human Recombinant produced in E. coli is a single polypeptide chain containing 314 amino acids (40-330) and having a molecular mass of 33.9kDa. TMEFF1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
TMEFF1, a type I transmembrane glycoprotein, plays a crucial role in cellular signaling. Its structure encompasses two follistatin modules, an EGF domain in the extracellular region, a transmembrane domain, and a short cytoplasmic tail. Notably, the extracellular domain can be released as a soluble protein. TMEFF1 exhibits predominant expression in the brain but experiences downregulation in brain tumors. Functionally, it selectively regulates nodal signaling, without affecting activin signaling, by directly interacting with the nodal co-receptor, Cripto. TMEFF1 exerts inhibitory effects on NODAL and BMP signaling pathways, influencing neural patterning. Furthermore, it is implicated as a potential tumor suppressor in brain cancers.
Description
Recombinant TMEFF1 Human, produced in E. coli, is a single polypeptide chain comprising 314 amino acids (40-330) with a molecular weight of 33.9 kDa. This protein is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic methods.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
TMEFF1 is supplied as a 0.25 mg/ml solution in 20mM Tris-HCl buffer (pH 8.0), containing 0.1M NaCl and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product should be kept at 4°C. For extended storage, freeze at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Repeated freezing and thawing should be avoided.
Purity
Purity exceeds 90% as determined by SDS-PAGE analysis.
Synonyms
C9orf2, CT120.1, H7365, TR-1, Tomoregulin-1, Transmembrane protein with EGF-like and one follistatin-like domain, TMEFF1.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSSNQPPGG GGGSGGDCPG GKGKSINCSE LNVRESDVRV CDESSCKYGG VCKEDGDGLK CACQFQCHTN YIPVCGSNGD TYQNECFLRR AACKHQKEIT VIARGPCYSD NGSGSGEGEE EGSGAEVHRK HSKCGPCKYK AECDEDAENV GCVCNIDCSG YSFNPVCASD GSSYNNPCFV REASCIKQEQ IDIRHLGHCT DTDDTSLLGK KDDGLQYRPD VKDASDQRED VYIGNHMPCP ENLNGYCIHG KCEFIYSTQK ASCRCESGYT GQHCEKTDFS ILYVVPSRQK LTHV.

Product Science Overview

Structure and Function

TMEFF1 is a transmembrane protein that is primarily located in the plasma membrane. It is involved in several critical biological processes, including neural patterning and tumor suppression. The protein is predicted to inhibit NODAL and BMP signaling pathways, which are crucial during neural development . Additionally, TMEFF1 has been suggested to act as a tumor suppressor in brain cancers .

Expression and Localization

The expression of TMEFF1 is predominantly observed in the central nervous system (CNS). It plays a significant role in the development and maintenance of neural tissues. The protein’s localization to the plasma membrane allows it to participate in cell signaling processes that are essential for neuron projection development and tissue morphogenesis .

Clinical Significance

TMEFF1 has been associated with various diseases, including acute promyelocytic leukemia and leukoencephalopathy with vanishing white matter . Its role as a tumor suppressor highlights its potential importance in cancer research, particularly in understanding the mechanisms underlying brain cancers .

Recent Research

Recent studies have identified TMEFF1 as a critical factor in controlling herpes simplex virus 1 (HSV-1) replication in the CNS. Depletion of TMEFF1 in human neurons and mice led to increased viral replication and neuronal death following HSV-1 infection . This discovery underscores the importance of TMEFF1 in the innate antiviral defense mechanisms of neurons and its potential therapeutic implications .

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