TMED10 Human
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Description
Product Specs
Product Science Overview
TMED10 is a type I membrane protein characterized by the presence of a GOLD (Golgi dynamics) domain. It is predominantly localized to the plasma membrane and the Golgi cisternae . The protein is also a part of a heteromeric secretase complex, where it regulates gamma-secretase activity without affecting epsilon-secretase activity .
The primary function of TMED10 involves acting as a cargo receptor in the vesicular trafficking pathway. It binds to coat protein complex I (COPI) and coat protein complex II (COPII), which are essential for the transport of proteins between the ER and Golgi . This protein is involved in both anterograde (ER to Golgi) and retrograde (Golgi to ER) transport, ensuring that proteins are correctly folded and modified before reaching their final destinations .
Mutations in the TMED10 gene have been associated with early-onset familial Alzheimer’s disease . The protein’s role in the secretory pathway is critical for maintaining cellular homeostasis, and disruptions in this pathway can lead to various diseases, including congenital malformations and cancers .
Research on TMED10 has expanded our understanding of the secretory pathway and its implications in human health and disease. The recombinant form of TMED10 is used in various studies to investigate its function and potential therapeutic applications. For instance, TMED10 has been shown to promote the unconventional protein secretion (UPS) of leaderless cargo, including mature IL-1β .
