TP 5

Thymopentin

Cat. No.

BT17546

Source

Synonyms

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Purity

Greater than 99.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Usage

THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

Thymopentin has a molecular formula of C₃₀H₄₉N₉O₉, Arg-Lys-Asp-Val-Tyr-OH having an Mw of 679.8 Dalton.

Product Specs

Introduction

Thymopentin (TP-5), a synthetic pentapeptide mimicking the active site of the natural hormone thymopoietin (amino acids 32-36), exhibits immunomodulatory properties. It boosts the production of thymic T cells, potentially restoring immunocompetence in individuals with suppressed immune systems. Additionally, thymopentin enhances the effects of ionizing radiation by halting cancer cell progression in the G2/M phase of the cell cycle.

Description

Thymopentin, with the chemical formula C₃₀H₄₉N₉O₉, represents the peptide sequence Arg-Lys-Asp-Val-Tyr-OH. It possesses a molecular weight of 679.8 Daltons.

Physical Appearance

White, sterile-filtered powder in lyophilized (freeze-dried) form.

Formulation

The protein is lyophilized at a concentration of 1 mg/ml without any additional ingredients.

Solubility

For reconstitution, dissolve the lyophilized Thymopentin in sterile 18MΩ-cm H2O to achieve a concentration of at least 100 µg/ml. This solution can be further diluted with other aqueous solutions as needed.

Stability

While lyophilized Thymopentin remains stable at room temperature for up to 3 weeks, it is recommended to store it desiccated below -18°C. Once reconstituted, TP-5 should be stored at 4°C for 2-7 days. For long-term storage, freeze at -18°C. It is advisable to add a carrier protein (0.1% HSA or BSA) for long-term storage and avoid repeated freeze-thaw cycles.

Purity

The purity is determined to be greater than 99.0% based on the following analyses: (a) Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) (b) Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE)

Product Science Overview

Chemical Structure and Properties

Thymopentin’s chemical formula is C30H49N9O9, and it has a molar mass of 679.776 g/mol. The structure of thymopentin allows it to interact effectively with T cells, which are crucial components of the immune system.

Mechanism of Action

Thymopentin enhances the production of thymic T cells, which play a vital role in the immune response. By stimulating these cells, thymopentin helps restore immunocompetence in immunosuppressed individuals. This makes it a valuable agent in the treatment of various conditions where the immune system is compromised.

Clinical Applications

Thymopentin has been studied for its potential use in treating several conditions, including:

AIDS: In the early years of the AIDS pandemic (1983-1985), thymopentin was used in clinical studies to improve the immunological condition of patients.
Rheumatoid Arthritis: Its immunomodulating properties have been explored for potential benefits in autoimmune diseases like rheumatoid arthritis.
Primary Immunodeficiencies: Thymopentin has been considered for use in other primary immunodeficiencies due to its ability to enhance immune function.

Research and Development

Thymopentin has been the subject of various studies to understand its binding mechanisms and effects on the immune system. For instance, molecular analysis has been conducted to investigate how thymopentin binds to HLA-DR molecules, which are involved in the immune response.

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TP 5

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