Thrombin Porcine
Description
Product Specs
Product Science Overview
Thrombin was first discovered in the late 19th century by a physiologist in Scotland. The enzyme was purified and sequenced in 1951, which significantly advanced the understanding of its structure and function . Since then, thrombin has been widely studied and applied in clinical settings due to its prominent hemostatic properties.
Porcine thrombin is typically extracted from fresh porcine blood using methods such as isoelectric precipitation and ammonium sulfate fractionation. The crude thrombin solution is then activated with a calcium solution and purified through chromatographic techniques, such as using a cellulose DEAE-52 column . The purified thrombin is often freeze-dried to obtain a white, pure form of the enzyme with high specific activity.
Porcine thrombin is widely used in medical and clinical settings as a hemostatic agent. It is particularly effective in controlling local bleeding from capillaries and small blood vessels, making it valuable in trauma care, surgery, and various medical procedures involving the oral cavity, ear-nose-throat, urinary, and alimentary canals . Thrombin can be applied directly to wounds in powder or solution form to control bleeding and promote clot formation. It is also used in combination with other drugs to create new dosage forms and as a raw material for various topical hemostatic agents.
One of the significant advantages of using porcine thrombin is its safety and convenience. It has no obvious adverse effects even when used in high doses or over extended periods. Unlike some other hemostatic agents, porcine thrombin does not induce antigenicity or allergic reactions when applied topically or orally . This makes it a preferred choice for many medical applications.
China is one of the leading producers of porcine blood, generating approximately 1 billion kilograms annually . However, much of this blood is often discarded as waste, leading to environmental pollution. By extracting thrombin from porcine blood, valuable biological resources can be utilized more efficiently, creating significant market value and reducing environmental impact .
