TBC1D22B Human

TBC1 Domain Family, Member 22B (TBC1D22B) is a protein-coding gene that belongs to the TBC (Tre-2/Bub2/Cdc16) domain family. This family is characterized by the presence of a TBC domain, which is known to be involved in the regulation of GTPase activity. TBC1D22B is also known by several aliases, including C6orf197, dJ744I24.2, and FLJ20337 .

The TBC1D22B gene is located on chromosome 6 and encodes a protein that is predicted to function as a GTPase-activating protein (GAP) for Rab family proteins . Rab proteins are small GTPases that play crucial roles in intracellular vesicle trafficking. The TBC1D22B protein is involved in the activation of GTPase activity and intracellular protein transport .

TBC1D22B is expressed in various tissues, including lymphoid tissue, bone marrow, testis, and skeletal muscle . It is involved in several biological processes, such as protein ubiquitination, immune response, and transmembrane transport . The protein interacts with multiple other proteins, indicating its involvement in complex cellular pathways .

The primary function of TBC1D22B is to act as a GTPase-activating protein for Rab family proteins, which are essential for the regulation of vesicle trafficking within cells . By modulating the activity of Rab proteins, TBC1D22B plays a critical role in maintaining cellular homeostasis and ensuring the proper transport of proteins and other molecules within the cell .

Research on TBC1D22B has revealed its potential involvement in various cellular processes and diseases. For instance, its role in protein ubiquitination and immune response suggests that it may be implicated in immune-related disorders and conditions involving protein degradation . Additionally, the study of TBC1D22B and its interactions with other proteins can provide insights into the molecular mechanisms underlying these processes and potentially lead to the development of targeted therapies.