TACSTD2 Human, sf9

Tumor-Associated Calcium Signal Transducer 2 Human Recombinant, Sf9
Cat. No.
BT22721
Source
Sf9, Baculovirus cells.
Synonyms
Tumor-Associated Calcium Signal Transducer 2,Membrane Component Chromosome 1 Surface Marker 1, Pancreatic Carcinoma Marker Protein GA733-1,Cell Surface Glycoprotein Trop-2, GA733-1,TROP2, M1S1, 40kD Glycoprotein, Identified By Monoclonal Antibody GA733,Membrane Component, Chromosome 1, Surface Marker 1, Gastrointestinal Tumor-Associated Antigen GA7331,Pancreatic Carcinoma Marker Protein GA7331,Cell Surface Glycoprotein TROP2,Epithelial Glycoprotein-1Truncated TACSTD2,GA7331,EGP-1,EGP1,GP50, TACSTD2.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

TACSTD2 Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 253 amino acids (31-274a.a) and having a molecular mass of 28.6kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).
TACSTD2 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Tumor-associated calcium signal transducer 2 (TACSTD2) belongs to the EPCAM family. This intronless gene encodes a carcinoma-associated antigen. TACSTD2 may function as a growth factor receptor and a cell surface receptor involved in calcium signal transduction. Mutations in TACSTD2 have been linked to gelatinous drop-like corneal dystrophy.
Description
Recombinant human TACSTD2 protein, expressed in Sf9 insect cells using a baculovirus system, is a single, non-glycosylated polypeptide chain. It comprises 253 amino acids (residues 31-274) and has a molecular weight of 28.6 kDa. Note: On SDS-PAGE, the apparent molecular size may appear between 28-40 kDa. The protein contains a C-terminal 6-amino acid His-tag and is purified using proprietary chromatographic methods.
Physical Appearance
Clear, colorless solution, sterile filtered.
Formulation
The TACSTD2 protein solution is provided at a concentration of 1 mg/ml in phosphate-buffered saline (pH 7.4) containing 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is greater than 95.0% as assessed by SDS-PAGE analysis.
Synonyms
Tumor-Associated Calcium Signal Transducer 2,Membrane Component Chromosome 1 Surface Marker 1, Pancreatic Carcinoma Marker Protein GA733-1,Cell Surface Glycoprotein Trop-2, GA733-1,TROP2, M1S1, 40kD Glycoprotein, Identified By Monoclonal Antibody GA733,Membrane Component, Chromosome 1, Surface Marker 1, Gastrointestinal Tumor-Associated Antigen GA7331,Pancreatic Carcinoma Marker Protein GA7331,Cell Surface Glycoprotein TROP2,Epithelial Glycoprotein-1Truncated TACSTD2,GA7331,EGP-1,EGP1,GP50, TACSTD2.
Source
Sf9, Baculovirus cells.
Amino Acid Sequence
ADPQDNCTCP TNKMTVCSPD GPGGRCQCRA LGSGMAVDCS TLTSKCLLLK ARMSAPKNAR TLVRPSEHAL VDNDGLYDPD CDPEGRFKAR QCNQTSVCWC VNSVGVRRTD KGDLSLRCDE LVRTHHILID LRHRPTAGAF NHSDLDAELR RLFRERYRLH PKFVAAVHYE QPTIQIELRQ
NTSQKAAGDV DIGDAAYYFE RDIKGESLFQ GRGGLDLRVR GEPLQVERTL IYYLDEIPPK FSMKRLTHHH HHH.

Product Science Overview

Role in Cancer

TACSTD2 is highly expressed in various types of cancers, including lung adenocarcinoma, hepatocellular carcinoma, cholangiocarcinoma, and renal cell carcinoma (RCC) . It participates in cell cycle progression through the MAPK signaling pathway . The hypermethylation of TACSTD2 has been associated with aggressive cancer characteristics and poor prognosis .

In non-small-cell lung cancer (NSCLC), TACSTD2 has been shown to regulate neovascularization via the ERK1/2 signaling pathway . Overexpression of TACSTD2 promotes cancer cell proliferation, invasion, and angiogenesis, making it a potential target for anti-angiogenesis therapy .

Clinical Implications

The methylation status of TACSTD2 can serve as a biomarker for the progression and clinical course of RCC . Higher methylation levels are significantly associated with advanced disease, high tumor stage, tumor differentiation, and the presence of lymph node or distant metastases . This makes TACSTD2 a valuable marker for predicting patient outcomes and tailoring personalized treatment strategies.

Human Recombinant TACSTD2 (Sf9)

The recombinant form of TACSTD2, produced in Sf9 insect cells, is used in various research applications. Sf9 cells are derived from the fall armyworm and are commonly used for the expression of recombinant proteins. The human recombinant TACSTD2 produced in these cells retains its biological activity and is used in studies to understand its role in cancer progression and to develop targeted therapies.

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TACSTD2 Human
Tumor-Associated Calcium Signal Transducer 2 Human Recombinant
Cat. No.
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Source
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