TAC3 Human

Tachykinin-3, also known as Neurokinin B, is a member of the tachykinin family of neuropeptides. These peptides are characterized by their ability to excite neurons, evoke behavioral responses, act as potent vasodilators and secretagogues, and contract various smooth muscles. Tachykinin-3 is encoded by the TAC3 gene in humans .

The TAC3 gene encodes a precursor protein that is proteolytically processed to generate the mature Tachykinin-3 peptide. This peptide is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. The mature peptide is the ligand for the neurokinin-3 receptor (NK3R), which is involved in various physiological processes .

Tachykinin-3 plays a critical role in the regulation of gonadal function. It is a central regulator of reproductive hormones and is involved in the modulation of the hypothalamic-pituitary-gonadal axis. This peptide is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia .

Mutations in the TAC3 gene are associated with normosmic hypogonadotropic hypogonadism, a condition characterized by delayed or absent puberty and impaired reproductive function. This condition can occur with or without anosmia (loss of the sense of smell). Tachykinin-3 is also being studied for its potential role in various other disorders, including infertility and certain types of cancer .

Human recombinant Tachykinin-3 is produced using recombinant DNA technology, which involves inserting the TAC3 gene into a suitable expression system, such as bacteria or yeast, to produce the peptide in large quantities. This recombinant form is used in research to study the physiological and pathological roles of Tachykinin-3 and to develop potential therapeutic applications .

Research on Tachykinin-3 has provided insights into its role in various physiological processes and its potential as a therapeutic target. For example, studies have shown that Tachykinin-3 and its receptor NK3R are involved in the regulation of mood, stress, and pain. Additionally, Tachykinin-3 analogs and antagonists are being explored for their potential use in treating conditions such as depression, anxiety, and chronic pain .