SYF2 Human

The SYF2 RNA splicing factor, also known as p29, CBPIN, or NTC31, is a nuclear protein encoded by the SYF2 gene. This protein plays a crucial role in the regulation of pre-mRNA splicing and cell cycle progression. The human recombinant form of SYF2 is produced through recombinant DNA technology, allowing for its use in various research and therapeutic applications.

The SYF2 gene is located on chromosome 1 and is a protein-coding gene. It encodes a nuclear protein that interacts with cyclin D-type binding-protein 1 (GICP), which is involved in cell cycle regulation at the G1/S transition . The gene undergoes alternative splicing, resulting in different isoforms of the SYF2 protein .

SYF2 is a component of the spliceosome, a complex responsible for the removal of introns from pre-mRNA transcripts. It is involved in the processing of capped intron-containing pre-mRNA, a critical step in the maturation of mRNA molecules . The protein’s RNA binding capability is essential for its function in the spliceosome .

SYF2 interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition . This interaction suggests that SYF2 may play a role in coordinating cell cycle progression with RNA splicing, ensuring that cells progress through the cell cycle in a regulated manner.

Research has shown that SYF2 is involved in cancer progression. Its role in cell cycle regulation and RNA splicing makes it a potential target for cancer therapy . Understanding the function and regulation of SYF2 can provide insights into the mechanisms underlying cancer development and progression.

The human recombinant form of SYF2 is used in various research applications, including studies on RNA splicing, cell cycle regulation, and cancer biology. Recombinant SYF2 can be used to investigate the protein’s function, interactions, and potential as a therapeutic target.