SYCE3 Human

Synaptonemal Complex Central Element Protein 3 Human Recombinant
Cat. No.
BT22242
Source
E.coli.
Synonyms
Synaptonemal complex central element protein 3, chromosome 22 open reading frame 41, Testis highly expressed gene 2 protein, testis highly expressed protein 2, THEG2, C22orf41.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

SYCE3 Human Recombinant produced in E. coli is a single polypeptide chain containing 108 amino acids (1-88) and having a molecular mass of 12.8 kDa.
SYCE3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
The protein Synaptonemal complex central element protein 3, abbreviated as SYCE3, is a crucial element of the synaptonemal complex's (SCS) transverse central element. During meiosis, a protein structure called the synaptonemal complex develops between homologous chromosomes (two pairs of sister chromatids), and it is thought to be involved in chromosome pairing, synapsis, and recombination (crossing-over). The SYCE3 protein is essential for both the loading of central element-specific SCS proteins onto chromosomes and the start of synapsis between homologous chromosomes. Additionally, SYCE3 is necessary for fertility.
Description
Produced in E. coli, Recombinant Human SYCE3 is a single polypeptide chain. It consists of 108 amino acids (specifically, amino acids 1 through 88) and has a molecular weight of 12.8 kDa. A 20 amino acid His-tag is fused to SYCE3 at the N-terminus. The protein is purified using proprietary chromatographic techniques.
Physical Appearance
A sterile filtered solution that is colorless.
Formulation
The SYCE3 solution has a concentration of 0.5 mg/ml and contains the following components: 20mM Tris-HCl buffer with a pH of 8.0, 200mM NaCl, 2mM DTT, and 20% glycerol.
Stability
If the entire vial will be used within 2 to 4 weeks, store the solution at 4 degrees Celsius. For longer storage periods, store the solution frozen at -20 degrees Celsius. For long-term storage, it is recommended to add a carrier protein such as 0.1% HSA or BSA. Avoid multiple freeze-thaw cycles.
Purity
Purity is determined by SDS-PAGE analysis and is greater than 90%.
Synonyms
Synaptonemal complex central element protein 3, chromosome 22 open reading frame 41, Testis highly expressed gene 2 protein, testis highly expressed protein 2, THEG2, C22orf41.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR TNPTLAESMR RLEDAFVNCK EEMEKNWQEL LHETKQRL

Product Science Overview

Introduction

The Synaptonemal Complex Central Element Protein 3 (SYCE3) is a critical component of the synaptonemal complex, a meiosis-specific structure that mediates the synapsis of homologous chromosomes. This process is essential for proper recombination and segregation during meiosis .

Structure and Function

SYCE3 is a protein-coding gene that plays a significant role in the formation and stabilization of the synaptonemal complex. It is a major component of the transverse central element of synaptonemal complexes (SCS), which are formed between homologous chromosomes during meiotic prophase . The protein is required for chromosome loading of the central element-specific SCS proteins and for initiating synapsis between homologous chromosomes .

Biological Significance

The synaptonemal complex is essential for the proper recombination and segregation of meiotic chromosomes. Defects in the assembly of the synaptonemal complex or in the function of associated meiotic recombination machinery can lead to meiotic arrest and human infertility . SYCE3 is required for fertility, and its proper function is crucial for the successful completion of meiosis .

Genetic Information

The SYCE3 gene is located on chromosome 22 and is highly expressed in the testis . It is involved in pathways related to meiosis and the cell cycle, particularly during the mitotic phase . Mutations in this gene have been associated with various disorders, including Cutis Laxa, Autosomal Recessive, Type IId, and Loeys-Dietz Syndrome 4 .

Research and Clinical Implications

Research on SYCE3 and the synaptonemal complex has significant implications for understanding human fertility and the genetic basis of infertility. Aberrant expression and malfunctioning of these genes have also been associated with cancer development . Understanding the role of SYCE3 in meiosis can provide insights into potential therapeutic targets for treating infertility and related disorders.

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